Cargando…
Salivary immunoglobulin A level during steroids and chemotherapy treatment administered in remission induction phase among pediatric patients with acute lymphoblastic leukemia
The agents used in the treatment of acute lymphoblastic leukaemia (ALL) might affect the oral health of cancer patients. The study aims to assess the changes in the levels of immunoglobulin A (IgA) in saliva and blood, during first 22 days of intensive chemotherapy of ALL in children. Saliva and blo...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571880/ https://www.ncbi.nlm.nih.gov/pubmed/33080754 http://dx.doi.org/10.1097/MD.0000000000022802 |
_version_ | 1783597236477755392 |
---|---|
author | Proc, Patrycja Szczepańska, Joanna Zubowska, Małgorzata Wyka, Krystyna Młynarski, Wojciech |
author_facet | Proc, Patrycja Szczepańska, Joanna Zubowska, Małgorzata Wyka, Krystyna Młynarski, Wojciech |
author_sort | Proc, Patrycja |
collection | PubMed |
description | The agents used in the treatment of acute lymphoblastic leukaemia (ALL) might affect the oral health of cancer patients. The study aims to assess the changes in the levels of immunoglobulin A (IgA) in saliva and blood, during first 22 days of intensive chemotherapy of ALL in children. Saliva and blood samples were taken from 24 patients, including 13 boys and 11 girls (age range: 4 – 17 years) on days 1, 8 and 22 of treatment. The levels of immunoglobulin A and total protein were estimated in samples at each time-point. The distribution of the quantitative variables was assessed using the Shapiro-Wilk test. Non-parametric statistics were used to compare the levels of repeated measurements and post hoc non-parametric analysis was applied for between time-point comparisons. A constant relationship was found between the levels of Ig A in blood and saliva (r = 0.28; P = .031). No change in salivary IgA level was observed in the prednisone-only prephase, but it dropped significantly on day 22 (10.7+/−4.8 vs 9.6+/−6.4 vs 5.7+/−3.9 ng/mL; P = .04), when chemotherapy was given (anthracycline, vincristine, L-asparaginase). In blood, the total protein level decreased significantly between day 1 and 22 (6.2+/−0.4 vs 5.1+/−0.3 g/dL; P = .001). Lymphocyte count (per microliter) also decreased (2.12+/−0.8 vs 0.41+/−0.1 vs 1.08+/−0.5; P = .002). Four children suffered from oral mucositis graded 1 or higher between days 8 and 22. Chemotherapy given during the treatment of childhood ALL is associated with a reduction in the level of salivary immunoglobulin A. Prevention of the drop of salivary IgA may diminish the risk of occurrence of acute mucosal complications. |
format | Online Article Text |
id | pubmed-7571880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-75718802020-10-29 Salivary immunoglobulin A level during steroids and chemotherapy treatment administered in remission induction phase among pediatric patients with acute lymphoblastic leukemia Proc, Patrycja Szczepańska, Joanna Zubowska, Małgorzata Wyka, Krystyna Młynarski, Wojciech Medicine (Baltimore) 5900 The agents used in the treatment of acute lymphoblastic leukaemia (ALL) might affect the oral health of cancer patients. The study aims to assess the changes in the levels of immunoglobulin A (IgA) in saliva and blood, during first 22 days of intensive chemotherapy of ALL in children. Saliva and blood samples were taken from 24 patients, including 13 boys and 11 girls (age range: 4 – 17 years) on days 1, 8 and 22 of treatment. The levels of immunoglobulin A and total protein were estimated in samples at each time-point. The distribution of the quantitative variables was assessed using the Shapiro-Wilk test. Non-parametric statistics were used to compare the levels of repeated measurements and post hoc non-parametric analysis was applied for between time-point comparisons. A constant relationship was found between the levels of Ig A in blood and saliva (r = 0.28; P = .031). No change in salivary IgA level was observed in the prednisone-only prephase, but it dropped significantly on day 22 (10.7+/−4.8 vs 9.6+/−6.4 vs 5.7+/−3.9 ng/mL; P = .04), when chemotherapy was given (anthracycline, vincristine, L-asparaginase). In blood, the total protein level decreased significantly between day 1 and 22 (6.2+/−0.4 vs 5.1+/−0.3 g/dL; P = .001). Lymphocyte count (per microliter) also decreased (2.12+/−0.8 vs 0.41+/−0.1 vs 1.08+/−0.5; P = .002). Four children suffered from oral mucositis graded 1 or higher between days 8 and 22. Chemotherapy given during the treatment of childhood ALL is associated with a reduction in the level of salivary immunoglobulin A. Prevention of the drop of salivary IgA may diminish the risk of occurrence of acute mucosal complications. Lippincott Williams & Wilkins 2020-10-16 /pmc/articles/PMC7571880/ /pubmed/33080754 http://dx.doi.org/10.1097/MD.0000000000022802 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 5900 Proc, Patrycja Szczepańska, Joanna Zubowska, Małgorzata Wyka, Krystyna Młynarski, Wojciech Salivary immunoglobulin A level during steroids and chemotherapy treatment administered in remission induction phase among pediatric patients with acute lymphoblastic leukemia |
title | Salivary immunoglobulin A level during steroids and chemotherapy treatment administered in remission induction phase among pediatric patients with acute lymphoblastic leukemia |
title_full | Salivary immunoglobulin A level during steroids and chemotherapy treatment administered in remission induction phase among pediatric patients with acute lymphoblastic leukemia |
title_fullStr | Salivary immunoglobulin A level during steroids and chemotherapy treatment administered in remission induction phase among pediatric patients with acute lymphoblastic leukemia |
title_full_unstemmed | Salivary immunoglobulin A level during steroids and chemotherapy treatment administered in remission induction phase among pediatric patients with acute lymphoblastic leukemia |
title_short | Salivary immunoglobulin A level during steroids and chemotherapy treatment administered in remission induction phase among pediatric patients with acute lymphoblastic leukemia |
title_sort | salivary immunoglobulin a level during steroids and chemotherapy treatment administered in remission induction phase among pediatric patients with acute lymphoblastic leukemia |
topic | 5900 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571880/ https://www.ncbi.nlm.nih.gov/pubmed/33080754 http://dx.doi.org/10.1097/MD.0000000000022802 |
work_keys_str_mv | AT procpatrycja salivaryimmunoglobulinalevelduringsteroidsandchemotherapytreatmentadministeredinremissioninductionphaseamongpediatricpatientswithacutelymphoblasticleukemia AT szczepanskajoanna salivaryimmunoglobulinalevelduringsteroidsandchemotherapytreatmentadministeredinremissioninductionphaseamongpediatricpatientswithacutelymphoblasticleukemia AT zubowskamałgorzata salivaryimmunoglobulinalevelduringsteroidsandchemotherapytreatmentadministeredinremissioninductionphaseamongpediatricpatientswithacutelymphoblasticleukemia AT wykakrystyna salivaryimmunoglobulinalevelduringsteroidsandchemotherapytreatmentadministeredinremissioninductionphaseamongpediatricpatientswithacutelymphoblasticleukemia AT młynarskiwojciech salivaryimmunoglobulinalevelduringsteroidsandchemotherapytreatmentadministeredinremissioninductionphaseamongpediatricpatientswithacutelymphoblasticleukemia |