Cargando…
A case report of acute pancreatitis with glycogen storage disease type IA in an adult patient and review of the literature
RATIONALE: Glycogen storage disease type IA (GSD IA) is an inherited disorder of glycogen metabolism characterized by fasting hypoglycemia, hyperuricemia, and hyperlipidemia including hypertriglyceridemia (HTG). Patients have a higher risk of developing acute pancreatitis (AP) because of HTG. AP is...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571931/ https://www.ncbi.nlm.nih.gov/pubmed/33080702 http://dx.doi.org/10.1097/MD.0000000000022644 |
_version_ | 1783597245687398400 |
---|---|
author | Ai, Jiaoyu He, Wenhua Huang, Xin Wu, Yao Lei, Yupeng Yu, Chen Görgülü, Kivanc Diakopoulos, Kalliope N. Lu, Nonghua Zhu, Yin |
author_facet | Ai, Jiaoyu He, Wenhua Huang, Xin Wu, Yao Lei, Yupeng Yu, Chen Görgülü, Kivanc Diakopoulos, Kalliope N. Lu, Nonghua Zhu, Yin |
author_sort | Ai, Jiaoyu |
collection | PubMed |
description | RATIONALE: Glycogen storage disease type IA (GSD IA) is an inherited disorder of glycogen metabolism characterized by fasting hypoglycemia, hyperuricemia, and hyperlipidemia including hypertriglyceridemia (HTG). Patients have a higher risk of developing acute pancreatitis (AP) because of HTG. AP is a potentially life-threatening disease with a wide spectrum severity. Nevertheless, almost no reports exist on GSD IA-induced AP in adult patients. PATIENT CONCERNS: A 23-year-old male patient with GSD 1A is presented, who developed moderate severe AP due to HTG. DIAGNOSES: The GSD 1A genetic background of this patient was confirmed by Sanger sequencing. Laboratory tests, along with abdominal enhanced-computed tomography, were used for the diagnosis of HTG and AP. INTERVENTIONS: This patient was transferred to the intensive care unit and treated by reducing HTG, suppressing gastric acid, inhibiting trypsin activity, and relieving hyperuricemia and gout. OUTCOMES: Fifteen days after hospital admission, the patient had no complaints about abdominal pain and distention. Follow-up of laboratory tests displayed almost normal values. Reexamination by computed tomography exhibited a reduction in peripancreatic necrotic fluid collection compared with the initial stage. LESSONS: Fast and long-term reduction of triglycerides along with management of AP proved effective in relieving suffering of an adult GSD IA-patient and improving prognosis. Thus, therapeutic approaches have to be renewed and standardized to cope with all complications, especially AP, and enable a better outcome so that patients can master the disease. |
format | Online Article Text |
id | pubmed-7571931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-75719312020-10-29 A case report of acute pancreatitis with glycogen storage disease type IA in an adult patient and review of the literature Ai, Jiaoyu He, Wenhua Huang, Xin Wu, Yao Lei, Yupeng Yu, Chen Görgülü, Kivanc Diakopoulos, Kalliope N. Lu, Nonghua Zhu, Yin Medicine (Baltimore) 4500 RATIONALE: Glycogen storage disease type IA (GSD IA) is an inherited disorder of glycogen metabolism characterized by fasting hypoglycemia, hyperuricemia, and hyperlipidemia including hypertriglyceridemia (HTG). Patients have a higher risk of developing acute pancreatitis (AP) because of HTG. AP is a potentially life-threatening disease with a wide spectrum severity. Nevertheless, almost no reports exist on GSD IA-induced AP in adult patients. PATIENT CONCERNS: A 23-year-old male patient with GSD 1A is presented, who developed moderate severe AP due to HTG. DIAGNOSES: The GSD 1A genetic background of this patient was confirmed by Sanger sequencing. Laboratory tests, along with abdominal enhanced-computed tomography, were used for the diagnosis of HTG and AP. INTERVENTIONS: This patient was transferred to the intensive care unit and treated by reducing HTG, suppressing gastric acid, inhibiting trypsin activity, and relieving hyperuricemia and gout. OUTCOMES: Fifteen days after hospital admission, the patient had no complaints about abdominal pain and distention. Follow-up of laboratory tests displayed almost normal values. Reexamination by computed tomography exhibited a reduction in peripancreatic necrotic fluid collection compared with the initial stage. LESSONS: Fast and long-term reduction of triglycerides along with management of AP proved effective in relieving suffering of an adult GSD IA-patient and improving prognosis. Thus, therapeutic approaches have to be renewed and standardized to cope with all complications, especially AP, and enable a better outcome so that patients can master the disease. Lippincott Williams & Wilkins 2020-10-16 /pmc/articles/PMC7571931/ /pubmed/33080702 http://dx.doi.org/10.1097/MD.0000000000022644 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 4500 Ai, Jiaoyu He, Wenhua Huang, Xin Wu, Yao Lei, Yupeng Yu, Chen Görgülü, Kivanc Diakopoulos, Kalliope N. Lu, Nonghua Zhu, Yin A case report of acute pancreatitis with glycogen storage disease type IA in an adult patient and review of the literature |
title | A case report of acute pancreatitis with glycogen storage disease type IA in an adult patient and review of the literature |
title_full | A case report of acute pancreatitis with glycogen storage disease type IA in an adult patient and review of the literature |
title_fullStr | A case report of acute pancreatitis with glycogen storage disease type IA in an adult patient and review of the literature |
title_full_unstemmed | A case report of acute pancreatitis with glycogen storage disease type IA in an adult patient and review of the literature |
title_short | A case report of acute pancreatitis with glycogen storage disease type IA in an adult patient and review of the literature |
title_sort | case report of acute pancreatitis with glycogen storage disease type ia in an adult patient and review of the literature |
topic | 4500 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571931/ https://www.ncbi.nlm.nih.gov/pubmed/33080702 http://dx.doi.org/10.1097/MD.0000000000022644 |
work_keys_str_mv | AT aijiaoyu acasereportofacutepancreatitiswithglycogenstoragediseasetypeiainanadultpatientandreviewoftheliterature AT hewenhua acasereportofacutepancreatitiswithglycogenstoragediseasetypeiainanadultpatientandreviewoftheliterature AT huangxin acasereportofacutepancreatitiswithglycogenstoragediseasetypeiainanadultpatientandreviewoftheliterature AT wuyao acasereportofacutepancreatitiswithglycogenstoragediseasetypeiainanadultpatientandreviewoftheliterature AT leiyupeng acasereportofacutepancreatitiswithglycogenstoragediseasetypeiainanadultpatientandreviewoftheliterature AT yuchen acasereportofacutepancreatitiswithglycogenstoragediseasetypeiainanadultpatientandreviewoftheliterature AT gorgulukivanc acasereportofacutepancreatitiswithglycogenstoragediseasetypeiainanadultpatientandreviewoftheliterature AT diakopouloskalliopen acasereportofacutepancreatitiswithglycogenstoragediseasetypeiainanadultpatientandreviewoftheliterature AT lunonghua acasereportofacutepancreatitiswithglycogenstoragediseasetypeiainanadultpatientandreviewoftheliterature AT zhuyin acasereportofacutepancreatitiswithglycogenstoragediseasetypeiainanadultpatientandreviewoftheliterature AT aijiaoyu casereportofacutepancreatitiswithglycogenstoragediseasetypeiainanadultpatientandreviewoftheliterature AT hewenhua casereportofacutepancreatitiswithglycogenstoragediseasetypeiainanadultpatientandreviewoftheliterature AT huangxin casereportofacutepancreatitiswithglycogenstoragediseasetypeiainanadultpatientandreviewoftheliterature AT wuyao casereportofacutepancreatitiswithglycogenstoragediseasetypeiainanadultpatientandreviewoftheliterature AT leiyupeng casereportofacutepancreatitiswithglycogenstoragediseasetypeiainanadultpatientandreviewoftheliterature AT yuchen casereportofacutepancreatitiswithglycogenstoragediseasetypeiainanadultpatientandreviewoftheliterature AT gorgulukivanc casereportofacutepancreatitiswithglycogenstoragediseasetypeiainanadultpatientandreviewoftheliterature AT diakopouloskalliopen casereportofacutepancreatitiswithglycogenstoragediseasetypeiainanadultpatientandreviewoftheliterature AT lunonghua casereportofacutepancreatitiswithglycogenstoragediseasetypeiainanadultpatientandreviewoftheliterature AT zhuyin casereportofacutepancreatitiswithglycogenstoragediseasetypeiainanadultpatientandreviewoftheliterature |