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Decreased stroke risk with combined traditional Chinese and western medicine in patients with ischemic heart disease: A real-world evidence

Both ischemic heart disease (IHD) and stroke are major causes of death worldwide. We investigated the effects of combined Traditional Chinese medicine (TCM) and western medicine (WM) on stroke risk in IHD patients. Taiwanese patients with IHD were enrolled in the TCM study during their outpatient vi...

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Autores principales: Cheng, Yu-Chen, Lu, Cheng-Nan, Hu, Wen-Long, Hsu, Chung Y., Su, Yuan-Chih, Hung, Yu-Chiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571976/
https://www.ncbi.nlm.nih.gov/pubmed/33080705
http://dx.doi.org/10.1097/MD.0000000000022654
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author Cheng, Yu-Chen
Lu, Cheng-Nan
Hu, Wen-Long
Hsu, Chung Y.
Su, Yuan-Chih
Hung, Yu-Chiang
author_facet Cheng, Yu-Chen
Lu, Cheng-Nan
Hu, Wen-Long
Hsu, Chung Y.
Su, Yuan-Chih
Hung, Yu-Chiang
author_sort Cheng, Yu-Chen
collection PubMed
description Both ischemic heart disease (IHD) and stroke are major causes of death worldwide. We investigated the effects of combined Traditional Chinese medicine (TCM) and western medicine (WM) on stroke risk in IHD patients. Taiwanese patients with IHD were enrolled in the TCM study during their outpatient visit. Stroke events after TCM or non-TCM treatment were examined. Chi-square tests and Student t-tests were used to examine differences between patients using and not using TCM. The Cox proportional hazards regression model was used to estimate hazard ratios (HRs). Sex, age, and comorbidities were included in a multivariable Cox model to estimate the adjusted HR (aHR). The survival probability and the probability free of stroke were calculated by the Kaplan–Meier method. There were 733 IHD patients using TCM and 733 using non-TCM treatment, with the same proportion of sex and age within each cohort. Using single Chinese herb such as Dan Shen, San Qi, or Chuan Xiong would have lower stroke events and lower aHR than non-TCM in IHD patients. There was 0.3-fold lower stroke risk in IHD patients with combination TCM and non-TCM treatment (95% CI = 0.11–0.84, P = .02). Moreover, the survival rate was higher (P < .001) and the incidence of hemorrhagic stroke was significantly lower (P = .04) in IHD patients with TCM treatment. IHD patients using combined TCM and WM had a higher survival rate and lower risk of new onset stroke, especially hemorrhagic stroke than those who did not use TCM treatment.
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spelling pubmed-75719762020-10-29 Decreased stroke risk with combined traditional Chinese and western medicine in patients with ischemic heart disease: A real-world evidence Cheng, Yu-Chen Lu, Cheng-Nan Hu, Wen-Long Hsu, Chung Y. Su, Yuan-Chih Hung, Yu-Chiang Medicine (Baltimore) 3800 Both ischemic heart disease (IHD) and stroke are major causes of death worldwide. We investigated the effects of combined Traditional Chinese medicine (TCM) and western medicine (WM) on stroke risk in IHD patients. Taiwanese patients with IHD were enrolled in the TCM study during their outpatient visit. Stroke events after TCM or non-TCM treatment were examined. Chi-square tests and Student t-tests were used to examine differences between patients using and not using TCM. The Cox proportional hazards regression model was used to estimate hazard ratios (HRs). Sex, age, and comorbidities were included in a multivariable Cox model to estimate the adjusted HR (aHR). The survival probability and the probability free of stroke were calculated by the Kaplan–Meier method. There were 733 IHD patients using TCM and 733 using non-TCM treatment, with the same proportion of sex and age within each cohort. Using single Chinese herb such as Dan Shen, San Qi, or Chuan Xiong would have lower stroke events and lower aHR than non-TCM in IHD patients. There was 0.3-fold lower stroke risk in IHD patients with combination TCM and non-TCM treatment (95% CI = 0.11–0.84, P = .02). Moreover, the survival rate was higher (P < .001) and the incidence of hemorrhagic stroke was significantly lower (P = .04) in IHD patients with TCM treatment. IHD patients using combined TCM and WM had a higher survival rate and lower risk of new onset stroke, especially hemorrhagic stroke than those who did not use TCM treatment. Lippincott Williams & Wilkins 2020-10-16 /pmc/articles/PMC7571976/ /pubmed/33080705 http://dx.doi.org/10.1097/MD.0000000000022654 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 3800
Cheng, Yu-Chen
Lu, Cheng-Nan
Hu, Wen-Long
Hsu, Chung Y.
Su, Yuan-Chih
Hung, Yu-Chiang
Decreased stroke risk with combined traditional Chinese and western medicine in patients with ischemic heart disease: A real-world evidence
title Decreased stroke risk with combined traditional Chinese and western medicine in patients with ischemic heart disease: A real-world evidence
title_full Decreased stroke risk with combined traditional Chinese and western medicine in patients with ischemic heart disease: A real-world evidence
title_fullStr Decreased stroke risk with combined traditional Chinese and western medicine in patients with ischemic heart disease: A real-world evidence
title_full_unstemmed Decreased stroke risk with combined traditional Chinese and western medicine in patients with ischemic heart disease: A real-world evidence
title_short Decreased stroke risk with combined traditional Chinese and western medicine in patients with ischemic heart disease: A real-world evidence
title_sort decreased stroke risk with combined traditional chinese and western medicine in patients with ischemic heart disease: a real-world evidence
topic 3800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571976/
https://www.ncbi.nlm.nih.gov/pubmed/33080705
http://dx.doi.org/10.1097/MD.0000000000022654
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