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Idiopathic membranous nephropathy in a patient diagnosed with IgG4-related disease: A case report
RATIONALE: Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a newly recognized, systemic disease. Membranous nephropathy is the most common glomerular lesion in IgG4- related kidney disease. However, the lack of relationship with IgG4-related kidney disease and monoclonal gammopathy of undetermin...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571987/ https://www.ncbi.nlm.nih.gov/pubmed/33080759 http://dx.doi.org/10.1097/MD.0000000000022817 |
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author | Ma, XiaoYing Xu, HaiPing Sun, Jing Yi Gedara, Yuresha Surangani Siyabalagaba Sun, FuYun |
author_facet | Ma, XiaoYing Xu, HaiPing Sun, Jing Yi Gedara, Yuresha Surangani Siyabalagaba Sun, FuYun |
author_sort | Ma, XiaoYing |
collection | PubMed |
description | RATIONALE: Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a newly recognized, systemic disease. Membranous nephropathy is the most common glomerular lesion in IgG4- related kidney disease. However, the lack of relationship with IgG4-related kidney disease and monoclonal gammopathy of undetermined significance (MGUS) warrants investigation of the potential mechanisms. PATIENT CONCERNS: A 62-year-old patient was diagnosed with IgG4-RD, tubulointerstitial nephritis, retroperitoneal fibrosis. After 2 years, she was presented with proteinuria, hypoproteinemia, facial, and bilateral lower limb edema. Furthermore, this patient exhibited deposits of IgG k of monoclonal hyperplasia, and bone marrow plasma cell count was 2.5%. DIAGNOSIS: The patient was diagnosed with nephrotic syndrome, acute kidney injury, and MGUS. The pathological diagnosis was IgG4-related tubulointerstitial nephritis, IgG4-related membranous nephropathy. INTERVENTIONS: The patient was treated with intravenous methylprednisolone (40 mg daily), which was changed to oral prednisone 50 mg/d after 2 months. OUTCOMES: After 1 month, the patient exhibited a rapid response only with corticosteroid, and experienced partial remission of serum albumin and proteinuria. LESSONS: This case may suggest a possible relationship between IgG4-RD and MGUS, provide some guidance for investigating the mechanism between them. |
format | Online Article Text |
id | pubmed-7571987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-75719872020-10-29 Idiopathic membranous nephropathy in a patient diagnosed with IgG4-related disease: A case report Ma, XiaoYing Xu, HaiPing Sun, Jing Yi Gedara, Yuresha Surangani Siyabalagaba Sun, FuYun Medicine (Baltimore) 5200 RATIONALE: Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a newly recognized, systemic disease. Membranous nephropathy is the most common glomerular lesion in IgG4- related kidney disease. However, the lack of relationship with IgG4-related kidney disease and monoclonal gammopathy of undetermined significance (MGUS) warrants investigation of the potential mechanisms. PATIENT CONCERNS: A 62-year-old patient was diagnosed with IgG4-RD, tubulointerstitial nephritis, retroperitoneal fibrosis. After 2 years, she was presented with proteinuria, hypoproteinemia, facial, and bilateral lower limb edema. Furthermore, this patient exhibited deposits of IgG k of monoclonal hyperplasia, and bone marrow plasma cell count was 2.5%. DIAGNOSIS: The patient was diagnosed with nephrotic syndrome, acute kidney injury, and MGUS. The pathological diagnosis was IgG4-related tubulointerstitial nephritis, IgG4-related membranous nephropathy. INTERVENTIONS: The patient was treated with intravenous methylprednisolone (40 mg daily), which was changed to oral prednisone 50 mg/d after 2 months. OUTCOMES: After 1 month, the patient exhibited a rapid response only with corticosteroid, and experienced partial remission of serum albumin and proteinuria. LESSONS: This case may suggest a possible relationship between IgG4-RD and MGUS, provide some guidance for investigating the mechanism between them. Lippincott Williams & Wilkins 2020-10-16 /pmc/articles/PMC7571987/ /pubmed/33080759 http://dx.doi.org/10.1097/MD.0000000000022817 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 5200 Ma, XiaoYing Xu, HaiPing Sun, Jing Yi Gedara, Yuresha Surangani Siyabalagaba Sun, FuYun Idiopathic membranous nephropathy in a patient diagnosed with IgG4-related disease: A case report |
title | Idiopathic membranous nephropathy in a patient diagnosed with IgG4-related disease: A case report |
title_full | Idiopathic membranous nephropathy in a patient diagnosed with IgG4-related disease: A case report |
title_fullStr | Idiopathic membranous nephropathy in a patient diagnosed with IgG4-related disease: A case report |
title_full_unstemmed | Idiopathic membranous nephropathy in a patient diagnosed with IgG4-related disease: A case report |
title_short | Idiopathic membranous nephropathy in a patient diagnosed with IgG4-related disease: A case report |
title_sort | idiopathic membranous nephropathy in a patient diagnosed with igg4-related disease: a case report |
topic | 5200 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571987/ https://www.ncbi.nlm.nih.gov/pubmed/33080759 http://dx.doi.org/10.1097/MD.0000000000022817 |
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