Cargando…

Adenomyoepithelioma with a human epidermal growth factor receptor 2-fluorescence in situ hybridization-confirmed ductal carcinoma in situ component: A case report and review of the literature

INTRODUCTION: Breast adenomyoepithelioma (AME) is a rare tumor composed of myoepithelial cells and ductal or luminal cells. Most cases of AME are benign, but rare cases in which either or both cell types exhibited malignant features have been reported. Due to its rarity, no diagnostic criteria for m...

Descripción completa

Detalles Bibliográficos
Autores principales: Amano, Yusuke, Sakaguchi-Tamba, Mio, Sasaki, Yumiko, Oshiro, Hisashi, Fukushima, Noriyoshi, Fujita, Takashi, Masuda, Shinobu, Niki, Toshiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572011/
https://www.ncbi.nlm.nih.gov/pubmed/33080708
http://dx.doi.org/10.1097/MD.0000000000022665
_version_ 1783597260360122368
author Amano, Yusuke
Sakaguchi-Tamba, Mio
Sasaki, Yumiko
Oshiro, Hisashi
Fukushima, Noriyoshi
Fujita, Takashi
Masuda, Shinobu
Niki, Toshiro
author_facet Amano, Yusuke
Sakaguchi-Tamba, Mio
Sasaki, Yumiko
Oshiro, Hisashi
Fukushima, Noriyoshi
Fujita, Takashi
Masuda, Shinobu
Niki, Toshiro
author_sort Amano, Yusuke
collection PubMed
description INTRODUCTION: Breast adenomyoepithelioma (AME) is a rare tumor composed of myoepithelial cells and ductal or luminal cells. Most cases of AME are benign, but rare cases in which either or both cell types exhibited malignant features have been reported. Due to its rarity, no diagnostic criteria for malignancy have been established for AME. PATIENT CONCERNS: A 64-year-old woman presented with a mass in her right breast. Fine-needle aspiration cytology and biopsy examinations revealed lesions composed of spindle-shaped cells and round epithelial cells. AME was suspected, and partial mastectomy was performed. DIAGNOSIS: The tumor specimen showed AME, which mainly consisted of spindle-shaped myoepithelial cells with slight atypia, admixed with tubular luminal cells and small areas of atypical intraductal proliferative lesions. No apparent features of malignancy, such as necrosis or invasion, were seen in the myoepithelial cells or the luminal or intraductal component. However, the atypical intraductal component exhibited focal nuclear atypia, a cribriform pattern, and moderate to strong membranous human epidermal growth factor receptor 2 (HER2) immunoreactivity. HER2 amplification was detected in focal regions of the atypical intraductal component by fluorescence in situ hybridization (FISH), which resulted in a diagnosis of AME with ductal carcinoma in situ. OUTCOMES: The patient did not receive further therapy and was free from tumor recurrence at 23 months after the operation. CONCLUSION: HER2 FISH might be useful for evaluating suspected AME tumors for malignancy when an atypical ductal lesion that lacks definitive features of malignancy is encountered.
format Online
Article
Text
id pubmed-7572011
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-75720112020-10-29 Adenomyoepithelioma with a human epidermal growth factor receptor 2-fluorescence in situ hybridization-confirmed ductal carcinoma in situ component: A case report and review of the literature Amano, Yusuke Sakaguchi-Tamba, Mio Sasaki, Yumiko Oshiro, Hisashi Fukushima, Noriyoshi Fujita, Takashi Masuda, Shinobu Niki, Toshiro Medicine (Baltimore) 4100 INTRODUCTION: Breast adenomyoepithelioma (AME) is a rare tumor composed of myoepithelial cells and ductal or luminal cells. Most cases of AME are benign, but rare cases in which either or both cell types exhibited malignant features have been reported. Due to its rarity, no diagnostic criteria for malignancy have been established for AME. PATIENT CONCERNS: A 64-year-old woman presented with a mass in her right breast. Fine-needle aspiration cytology and biopsy examinations revealed lesions composed of spindle-shaped cells and round epithelial cells. AME was suspected, and partial mastectomy was performed. DIAGNOSIS: The tumor specimen showed AME, which mainly consisted of spindle-shaped myoepithelial cells with slight atypia, admixed with tubular luminal cells and small areas of atypical intraductal proliferative lesions. No apparent features of malignancy, such as necrosis or invasion, were seen in the myoepithelial cells or the luminal or intraductal component. However, the atypical intraductal component exhibited focal nuclear atypia, a cribriform pattern, and moderate to strong membranous human epidermal growth factor receptor 2 (HER2) immunoreactivity. HER2 amplification was detected in focal regions of the atypical intraductal component by fluorescence in situ hybridization (FISH), which resulted in a diagnosis of AME with ductal carcinoma in situ. OUTCOMES: The patient did not receive further therapy and was free from tumor recurrence at 23 months after the operation. CONCLUSION: HER2 FISH might be useful for evaluating suspected AME tumors for malignancy when an atypical ductal lesion that lacks definitive features of malignancy is encountered. Lippincott Williams & Wilkins 2020-10-16 /pmc/articles/PMC7572011/ /pubmed/33080708 http://dx.doi.org/10.1097/MD.0000000000022665 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 4100
Amano, Yusuke
Sakaguchi-Tamba, Mio
Sasaki, Yumiko
Oshiro, Hisashi
Fukushima, Noriyoshi
Fujita, Takashi
Masuda, Shinobu
Niki, Toshiro
Adenomyoepithelioma with a human epidermal growth factor receptor 2-fluorescence in situ hybridization-confirmed ductal carcinoma in situ component: A case report and review of the literature
title Adenomyoepithelioma with a human epidermal growth factor receptor 2-fluorescence in situ hybridization-confirmed ductal carcinoma in situ component: A case report and review of the literature
title_full Adenomyoepithelioma with a human epidermal growth factor receptor 2-fluorescence in situ hybridization-confirmed ductal carcinoma in situ component: A case report and review of the literature
title_fullStr Adenomyoepithelioma with a human epidermal growth factor receptor 2-fluorescence in situ hybridization-confirmed ductal carcinoma in situ component: A case report and review of the literature
title_full_unstemmed Adenomyoepithelioma with a human epidermal growth factor receptor 2-fluorescence in situ hybridization-confirmed ductal carcinoma in situ component: A case report and review of the literature
title_short Adenomyoepithelioma with a human epidermal growth factor receptor 2-fluorescence in situ hybridization-confirmed ductal carcinoma in situ component: A case report and review of the literature
title_sort adenomyoepithelioma with a human epidermal growth factor receptor 2-fluorescence in situ hybridization-confirmed ductal carcinoma in situ component: a case report and review of the literature
topic 4100
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572011/
https://www.ncbi.nlm.nih.gov/pubmed/33080708
http://dx.doi.org/10.1097/MD.0000000000022665
work_keys_str_mv AT amanoyusuke adenomyoepitheliomawithahumanepidermalgrowthfactorreceptor2fluorescenceinsituhybridizationconfirmedductalcarcinomainsitucomponentacasereportandreviewoftheliterature
AT sakaguchitambamio adenomyoepitheliomawithahumanepidermalgrowthfactorreceptor2fluorescenceinsituhybridizationconfirmedductalcarcinomainsitucomponentacasereportandreviewoftheliterature
AT sasakiyumiko adenomyoepitheliomawithahumanepidermalgrowthfactorreceptor2fluorescenceinsituhybridizationconfirmedductalcarcinomainsitucomponentacasereportandreviewoftheliterature
AT oshirohisashi adenomyoepitheliomawithahumanepidermalgrowthfactorreceptor2fluorescenceinsituhybridizationconfirmedductalcarcinomainsitucomponentacasereportandreviewoftheliterature
AT fukushimanoriyoshi adenomyoepitheliomawithahumanepidermalgrowthfactorreceptor2fluorescenceinsituhybridizationconfirmedductalcarcinomainsitucomponentacasereportandreviewoftheliterature
AT fujitatakashi adenomyoepitheliomawithahumanepidermalgrowthfactorreceptor2fluorescenceinsituhybridizationconfirmedductalcarcinomainsitucomponentacasereportandreviewoftheliterature
AT masudashinobu adenomyoepitheliomawithahumanepidermalgrowthfactorreceptor2fluorescenceinsituhybridizationconfirmedductalcarcinomainsitucomponentacasereportandreviewoftheliterature
AT nikitoshiro adenomyoepitheliomawithahumanepidermalgrowthfactorreceptor2fluorescenceinsituhybridizationconfirmedductalcarcinomainsitucomponentacasereportandreviewoftheliterature