Repurposing Antimalarials to Tackle the COVID-19 Pandemic

Artemisinin-based combination therapies (ACTs) have demonstrated in vitro inhibition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Artemisinins have also shown anti-inflammatory effects, including inhibition of interleukin-6 (IL-6) that plays a key role in the development of sever...

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Autores principales: Krishna, Sanjeev, Augustin, Yolanda, Wang, Jigang, Xu, Chengchao, Staines, Henry M., Platteeuw, Hans, Kamarulzaman, Adeeba, Sall, Amadou, Kremsner, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2021
Materias:
Forum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572038/
https://www.ncbi.nlm.nih.gov/pubmed/33153922
http://dx.doi.org/10.1016/j.pt.2020.10.003
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author Krishna, Sanjeev
Augustin, Yolanda
Wang, Jigang
Xu, Chengchao
Staines, Henry M.
Platteeuw, Hans
Kamarulzaman, Adeeba
Sall, Amadou
Kremsner, Peter
author_facet Krishna, Sanjeev
Augustin, Yolanda
Wang, Jigang
Xu, Chengchao
Staines, Henry M.
Platteeuw, Hans
Kamarulzaman, Adeeba
Sall, Amadou
Kremsner, Peter
author_sort Krishna, Sanjeev
collection PubMed
description Artemisinin-based combination therapies (ACTs) have demonstrated in vitro inhibition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Artemisinins have also shown anti-inflammatory effects, including inhibition of interleukin-6 (IL-6) that plays a key role in the development of severe coronavirus disease 2019 (COVID-19). There is now sufficient evidence for the effectiveness of ACTs, and in particular artesunate/pyronaridine, to support clinical studies for COVID-19 infections.
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spelling pubmed-75720382020-10-20 Repurposing Antimalarials to Tackle the COVID-19 Pandemic Krishna, Sanjeev Augustin, Yolanda Wang, Jigang Xu, Chengchao Staines, Henry M. Platteeuw, Hans Kamarulzaman, Adeeba Sall, Amadou Kremsner, Peter Trends Parasitol Forum Artemisinin-based combination therapies (ACTs) have demonstrated in vitro inhibition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Artemisinins have also shown anti-inflammatory effects, including inhibition of interleukin-6 (IL-6) that plays a key role in the development of severe coronavirus disease 2019 (COVID-19). There is now sufficient evidence for the effectiveness of ACTs, and in particular artesunate/pyronaridine, to support clinical studies for COVID-19 infections. Published by Elsevier Ltd. 2021-01 2020-10-19 /pmc/articles/PMC7572038/ /pubmed/33153922 http://dx.doi.org/10.1016/j.pt.2020.10.003 Text en © 2020 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Forum
Krishna, Sanjeev
Augustin, Yolanda
Wang, Jigang
Xu, Chengchao
Staines, Henry M.
Platteeuw, Hans
Kamarulzaman, Adeeba
Sall, Amadou
Kremsner, Peter
Repurposing Antimalarials to Tackle the COVID-19 Pandemic
title Repurposing Antimalarials to Tackle the COVID-19 Pandemic
title_full Repurposing Antimalarials to Tackle the COVID-19 Pandemic
title_fullStr Repurposing Antimalarials to Tackle the COVID-19 Pandemic
title_full_unstemmed Repurposing Antimalarials to Tackle the COVID-19 Pandemic
title_short Repurposing Antimalarials to Tackle the COVID-19 Pandemic
title_sort repurposing antimalarials to tackle the covid-19 pandemic
topic Forum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572038/
https://www.ncbi.nlm.nih.gov/pubmed/33153922
http://dx.doi.org/10.1016/j.pt.2020.10.003
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