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Intestinal microbiology shapes population health impacts of diet and lifestyle risk exposures in Torres Strait Islander communities

Poor diet and lifestyle exposures are implicated in substantial global increases in non-communicable disease burden in low-income, remote, and Indigenous communities. This observational study investigated the contribution of the fecal microbiome to influence host physiology in two Indigenous communi...

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Autores principales: Mobegi, Fredrick M, Leong, Lex EX, Thompson, Fintan, Taylor, Sean M, Harriss, Linton R, Choo, Jocelyn M, Taylor, Steven L, Wesselingh, Steve L, McDermott, Robyn, Ivey, Kerry L, Rogers, Geraint B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572126/
https://www.ncbi.nlm.nih.gov/pubmed/33074097
http://dx.doi.org/10.7554/eLife.58407
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author Mobegi, Fredrick M
Leong, Lex EX
Thompson, Fintan
Taylor, Sean M
Harriss, Linton R
Choo, Jocelyn M
Taylor, Steven L
Wesselingh, Steve L
McDermott, Robyn
Ivey, Kerry L
Rogers, Geraint B
author_facet Mobegi, Fredrick M
Leong, Lex EX
Thompson, Fintan
Taylor, Sean M
Harriss, Linton R
Choo, Jocelyn M
Taylor, Steven L
Wesselingh, Steve L
McDermott, Robyn
Ivey, Kerry L
Rogers, Geraint B
author_sort Mobegi, Fredrick M
collection PubMed
description Poor diet and lifestyle exposures are implicated in substantial global increases in non-communicable disease burden in low-income, remote, and Indigenous communities. This observational study investigated the contribution of the fecal microbiome to influence host physiology in two Indigenous communities in the Torres Strait Islands: Mer, a remote island where a traditional diet predominates, and Waiben a more accessible island with greater access to takeaway food and alcohol. Counterintuitively, disease markers were more pronounced in Mer residents. However, island-specific differences in disease risk were explained, in part, by microbiome traits. The absence of Alistipes onderdonkii, for example, significantly (p=0.014) moderated island-specific patterns of systolic blood pressure in multivariate-adjusted models. We also report mediatory relationships between traits of the fecal metagenome, disease markers, and risk exposures. Understanding how intestinal microbiome traits influence response to disease risk exposures is critical for the development of strategies that mitigate the growing burden of cardiometabolic disease in these communities.
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spelling pubmed-75721262020-10-21 Intestinal microbiology shapes population health impacts of diet and lifestyle risk exposures in Torres Strait Islander communities Mobegi, Fredrick M Leong, Lex EX Thompson, Fintan Taylor, Sean M Harriss, Linton R Choo, Jocelyn M Taylor, Steven L Wesselingh, Steve L McDermott, Robyn Ivey, Kerry L Rogers, Geraint B eLife Epidemiology and Global Health Poor diet and lifestyle exposures are implicated in substantial global increases in non-communicable disease burden in low-income, remote, and Indigenous communities. This observational study investigated the contribution of the fecal microbiome to influence host physiology in two Indigenous communities in the Torres Strait Islands: Mer, a remote island where a traditional diet predominates, and Waiben a more accessible island with greater access to takeaway food and alcohol. Counterintuitively, disease markers were more pronounced in Mer residents. However, island-specific differences in disease risk were explained, in part, by microbiome traits. The absence of Alistipes onderdonkii, for example, significantly (p=0.014) moderated island-specific patterns of systolic blood pressure in multivariate-adjusted models. We also report mediatory relationships between traits of the fecal metagenome, disease markers, and risk exposures. Understanding how intestinal microbiome traits influence response to disease risk exposures is critical for the development of strategies that mitigate the growing burden of cardiometabolic disease in these communities. eLife Sciences Publications, Ltd 2020-10-19 /pmc/articles/PMC7572126/ /pubmed/33074097 http://dx.doi.org/10.7554/eLife.58407 Text en © 2020, Mobegi et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Epidemiology and Global Health
Mobegi, Fredrick M
Leong, Lex EX
Thompson, Fintan
Taylor, Sean M
Harriss, Linton R
Choo, Jocelyn M
Taylor, Steven L
Wesselingh, Steve L
McDermott, Robyn
Ivey, Kerry L
Rogers, Geraint B
Intestinal microbiology shapes population health impacts of diet and lifestyle risk exposures in Torres Strait Islander communities
title Intestinal microbiology shapes population health impacts of diet and lifestyle risk exposures in Torres Strait Islander communities
title_full Intestinal microbiology shapes population health impacts of diet and lifestyle risk exposures in Torres Strait Islander communities
title_fullStr Intestinal microbiology shapes population health impacts of diet and lifestyle risk exposures in Torres Strait Islander communities
title_full_unstemmed Intestinal microbiology shapes population health impacts of diet and lifestyle risk exposures in Torres Strait Islander communities
title_short Intestinal microbiology shapes population health impacts of diet and lifestyle risk exposures in Torres Strait Islander communities
title_sort intestinal microbiology shapes population health impacts of diet and lifestyle risk exposures in torres strait islander communities
topic Epidemiology and Global Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572126/
https://www.ncbi.nlm.nih.gov/pubmed/33074097
http://dx.doi.org/10.7554/eLife.58407
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