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Alzheimer’s disease: natural products as inhibitors of neuroinflammation
Alzheimer’s disease (AD) is the most common form of dementia and affects 44 million people worldwide. New emerging evidence from pre-clinical and clinical investigations shows that neuroinflammation is a major pathological component of AD suggesting that anti-inflammatory strategies are important in...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572326/ https://www.ncbi.nlm.nih.gov/pubmed/32930914 http://dx.doi.org/10.1007/s10787-020-00751-1 |
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author | Olajide, Olumayokun A. Sarker, Satyajit D. |
author_facet | Olajide, Olumayokun A. Sarker, Satyajit D. |
author_sort | Olajide, Olumayokun A. |
collection | PubMed |
description | Alzheimer’s disease (AD) is the most common form of dementia and affects 44 million people worldwide. New emerging evidence from pre-clinical and clinical investigations shows that neuroinflammation is a major pathological component of AD suggesting that anti-inflammatory strategies are important in delaying the onset or slowing the progression of the disease. However, efforts to employ current anti-inflammatory agents in AD clinical trials have produced limited success. Consequently, there is a need to explore anti-inflammatory natural products, which target neuroinflammatory pathways relevant to AD pathogenesis. This review summarises important druggable molecular targets of neuroinflammation and presents classes of anti-neuroinflammatory natural products with potentials for preventing and reducing symptoms of AD. |
format | Online Article Text |
id | pubmed-7572326 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-75723262020-10-20 Alzheimer’s disease: natural products as inhibitors of neuroinflammation Olajide, Olumayokun A. Sarker, Satyajit D. Inflammopharmacology Review Alzheimer’s disease (AD) is the most common form of dementia and affects 44 million people worldwide. New emerging evidence from pre-clinical and clinical investigations shows that neuroinflammation is a major pathological component of AD suggesting that anti-inflammatory strategies are important in delaying the onset or slowing the progression of the disease. However, efforts to employ current anti-inflammatory agents in AD clinical trials have produced limited success. Consequently, there is a need to explore anti-inflammatory natural products, which target neuroinflammatory pathways relevant to AD pathogenesis. This review summarises important druggable molecular targets of neuroinflammation and presents classes of anti-neuroinflammatory natural products with potentials for preventing and reducing symptoms of AD. Springer International Publishing 2020-09-15 2020 /pmc/articles/PMC7572326/ /pubmed/32930914 http://dx.doi.org/10.1007/s10787-020-00751-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Olajide, Olumayokun A. Sarker, Satyajit D. Alzheimer’s disease: natural products as inhibitors of neuroinflammation |
title | Alzheimer’s disease: natural products as inhibitors of neuroinflammation |
title_full | Alzheimer’s disease: natural products as inhibitors of neuroinflammation |
title_fullStr | Alzheimer’s disease: natural products as inhibitors of neuroinflammation |
title_full_unstemmed | Alzheimer’s disease: natural products as inhibitors of neuroinflammation |
title_short | Alzheimer’s disease: natural products as inhibitors of neuroinflammation |
title_sort | alzheimer’s disease: natural products as inhibitors of neuroinflammation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572326/ https://www.ncbi.nlm.nih.gov/pubmed/32930914 http://dx.doi.org/10.1007/s10787-020-00751-1 |
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