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Alzheimer’s disease: natural products as inhibitors of neuroinflammation

Alzheimer’s disease (AD) is the most common form of dementia and affects 44 million people worldwide. New emerging evidence from pre-clinical and clinical investigations shows that neuroinflammation is a major pathological component of AD suggesting that anti-inflammatory strategies are important in...

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Autores principales: Olajide, Olumayokun A., Sarker, Satyajit D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572326/
https://www.ncbi.nlm.nih.gov/pubmed/32930914
http://dx.doi.org/10.1007/s10787-020-00751-1
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author Olajide, Olumayokun A.
Sarker, Satyajit D.
author_facet Olajide, Olumayokun A.
Sarker, Satyajit D.
author_sort Olajide, Olumayokun A.
collection PubMed
description Alzheimer’s disease (AD) is the most common form of dementia and affects 44 million people worldwide. New emerging evidence from pre-clinical and clinical investigations shows that neuroinflammation is a major pathological component of AD suggesting that anti-inflammatory strategies are important in delaying the onset or slowing the progression of the disease. However, efforts to employ current anti-inflammatory agents in AD clinical trials have produced limited success. Consequently, there is a need to explore anti-inflammatory natural products, which target neuroinflammatory pathways relevant to AD pathogenesis. This review summarises important druggable molecular targets of neuroinflammation and presents classes of anti-neuroinflammatory natural products with potentials for preventing and reducing symptoms of AD.
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spelling pubmed-75723262020-10-20 Alzheimer’s disease: natural products as inhibitors of neuroinflammation Olajide, Olumayokun A. Sarker, Satyajit D. Inflammopharmacology Review Alzheimer’s disease (AD) is the most common form of dementia and affects 44 million people worldwide. New emerging evidence from pre-clinical and clinical investigations shows that neuroinflammation is a major pathological component of AD suggesting that anti-inflammatory strategies are important in delaying the onset or slowing the progression of the disease. However, efforts to employ current anti-inflammatory agents in AD clinical trials have produced limited success. Consequently, there is a need to explore anti-inflammatory natural products, which target neuroinflammatory pathways relevant to AD pathogenesis. This review summarises important druggable molecular targets of neuroinflammation and presents classes of anti-neuroinflammatory natural products with potentials for preventing and reducing symptoms of AD. Springer International Publishing 2020-09-15 2020 /pmc/articles/PMC7572326/ /pubmed/32930914 http://dx.doi.org/10.1007/s10787-020-00751-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Olajide, Olumayokun A.
Sarker, Satyajit D.
Alzheimer’s disease: natural products as inhibitors of neuroinflammation
title Alzheimer’s disease: natural products as inhibitors of neuroinflammation
title_full Alzheimer’s disease: natural products as inhibitors of neuroinflammation
title_fullStr Alzheimer’s disease: natural products as inhibitors of neuroinflammation
title_full_unstemmed Alzheimer’s disease: natural products as inhibitors of neuroinflammation
title_short Alzheimer’s disease: natural products as inhibitors of neuroinflammation
title_sort alzheimer’s disease: natural products as inhibitors of neuroinflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572326/
https://www.ncbi.nlm.nih.gov/pubmed/32930914
http://dx.doi.org/10.1007/s10787-020-00751-1
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