Codon optimization with deep learning to enhance protein expression

Heterologous expression is the main approach for recombinant protein production ingenetic synthesis, for which codon optimization is necessary. The existing optimization methods are based on biological indexes. In this paper, we propose a novel codon optimization method based on deep learning. First...

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Detalles Bibliográficos
Autores principales: Fu, Hongguang, Liang, Yanbing, Zhong, Xiuqin, Pan, ZhiLing, Huang, Lei, Zhang, HaiLin, Xu, Yang, Zhou, Wei, Liu, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572362/
https://www.ncbi.nlm.nih.gov/pubmed/33077783
http://dx.doi.org/10.1038/s41598-020-74091-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572362/
https://www.ncbi.nlm.nih.gov/pubmed/33077783
http://dx.doi.org/10.1038/s41598-020-74091-z

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