Preferential transcription of the mutated allele in NPM1 mutated acute myeloid leukaemia

Nucleophosmin is commonly both over-expressed and mutated in acute myeloid leukemia (AML). NPM1 mutations are always heterozygous. In addition, NPM1 has a number of different splice variants with the major variant encoded by exons 1–9 and 11–12 (NPM1.1). Further variants include NPM1.2 which lacks e...

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Detalles Bibliográficos
Autores principales: Bailey, G. D., Doolan, L., Baskar, A., Smith, L. C., Seedhouse, C. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572395/
https://www.ncbi.nlm.nih.gov/pubmed/33077765
http://dx.doi.org/10.1038/s41598-020-73782-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572395/
https://www.ncbi.nlm.nih.gov/pubmed/33077765
http://dx.doi.org/10.1038/s41598-020-73782-x

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