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Hepatitis B-related hepatocellular carcinoma in a 36-year-old pregnant woman: prognosis and management dilemma

Management of chronic hepatitis B infection complicated by hepatocellular carcinoma (HCC) in pregnancy poses a treatment dilemma as the pregnancy accelerates disease progression and narrows the diagnostic tools and therapeutic choices. Studies have reported higher maternal and fetal losses. We share...

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Autores principales: Wembulua, Bruce Shinga, Diallo, Kalilou, Thioubou, Mame Aïsse, Nguma, Jean Didier Bosenge, Manga, Noel Magloire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572658/
https://www.ncbi.nlm.nih.gov/pubmed/33117492
http://dx.doi.org/10.11604/pamj.2020.36.298.22658
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author Wembulua, Bruce Shinga
Diallo, Kalilou
Thioubou, Mame Aïsse
Nguma, Jean Didier Bosenge
Manga, Noel Magloire
author_facet Wembulua, Bruce Shinga
Diallo, Kalilou
Thioubou, Mame Aïsse
Nguma, Jean Didier Bosenge
Manga, Noel Magloire
author_sort Wembulua, Bruce Shinga
collection PubMed
description Management of chronic hepatitis B infection complicated by hepatocellular carcinoma (HCC) in pregnancy poses a treatment dilemma as the pregnancy accelerates disease progression and narrows the diagnostic tools and therapeutic choices. Studies have reported higher maternal and fetal losses. We share our experience with a 36-year-old pregnant woman who presented at 35 weeks' gestation with a large painful nodular liver and significant weight loss. She tested HBsAg-positive and had both clinical and laboratory features of severe liver decompensation. The abdominal ultrasound rightly described HCC on a cirrhotic background. The fetus was delivered by cesarean section but the mother died soon after.
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spelling pubmed-75726582020-10-27 Hepatitis B-related hepatocellular carcinoma in a 36-year-old pregnant woman: prognosis and management dilemma Wembulua, Bruce Shinga Diallo, Kalilou Thioubou, Mame Aïsse Nguma, Jean Didier Bosenge Manga, Noel Magloire Pan Afr Med J Case Report Management of chronic hepatitis B infection complicated by hepatocellular carcinoma (HCC) in pregnancy poses a treatment dilemma as the pregnancy accelerates disease progression and narrows the diagnostic tools and therapeutic choices. Studies have reported higher maternal and fetal losses. We share our experience with a 36-year-old pregnant woman who presented at 35 weeks' gestation with a large painful nodular liver and significant weight loss. She tested HBsAg-positive and had both clinical and laboratory features of severe liver decompensation. The abdominal ultrasound rightly described HCC on a cirrhotic background. The fetus was delivered by cesarean section but the mother died soon after. The African Field Epidemiology Network 2020-08-18 /pmc/articles/PMC7572658/ /pubmed/33117492 http://dx.doi.org/10.11604/pamj.2020.36.298.22658 Text en Copyright: Bruce Shinga Wembulua et al. https://creativecommons.org/licenses/by/4.0 The Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Wembulua, Bruce Shinga
Diallo, Kalilou
Thioubou, Mame Aïsse
Nguma, Jean Didier Bosenge
Manga, Noel Magloire
Hepatitis B-related hepatocellular carcinoma in a 36-year-old pregnant woman: prognosis and management dilemma
title Hepatitis B-related hepatocellular carcinoma in a 36-year-old pregnant woman: prognosis and management dilemma
title_full Hepatitis B-related hepatocellular carcinoma in a 36-year-old pregnant woman: prognosis and management dilemma
title_fullStr Hepatitis B-related hepatocellular carcinoma in a 36-year-old pregnant woman: prognosis and management dilemma
title_full_unstemmed Hepatitis B-related hepatocellular carcinoma in a 36-year-old pregnant woman: prognosis and management dilemma
title_short Hepatitis B-related hepatocellular carcinoma in a 36-year-old pregnant woman: prognosis and management dilemma
title_sort hepatitis b-related hepatocellular carcinoma in a 36-year-old pregnant woman: prognosis and management dilemma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572658/
https://www.ncbi.nlm.nih.gov/pubmed/33117492
http://dx.doi.org/10.11604/pamj.2020.36.298.22658
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