Cargando…

STING cyclic dinucleotide sensing originated in bacteria

Stimulator of interferon genes (STING) is a receptor in human cells that senses foreign cyclic dinucleotides released during bacterial infection and endogenous cyclic GMP–AMP signaling during viral infection and antitumor immunity(1–5). STING shares no structural homology with other known signaling...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morehouse, Benjamin R., Govande, Apurva A., Millman, Adi, Keszei, Alexander F.A., Lowey, Brianna, Ofir, Gal, Shao, Sichen, Sorek, Rotem, Kranzusch, Philip J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572726/ https://www.ncbi.nlm.nih.gov/pubmed/32877915 http://dx.doi.org/10.1038/s41586-020-2719-5

Ejemplares similares

Cryo-EM structure of an active bacterial TIR–STING filament complex
por: Morehouse, Benjamin R., et al.
Publicado: (2022)

STING inhibitors target the cyclic dinucleotide binding pocket
por: Hong, Ze, et al.
Publicado: (2021)

Computational prediction of regulatory, premature transcription termination in bacteria
por: Millman, Adi, et al.
Publicado: (2017)

Cyclic Dinucleotides in Oral Bacteria and in Oral Biofilms
por: Gürsoy, Ulvi K., et al.
Publicado: (2017)

Cryo-EM structure of the RADAR supramolecular anti-phage defense complex
por: Duncan-Lowey, Brianna, et al.
Publicado: (2023)

Endosomolytic Polymersomes Increase the Activity of Cyclic Dinucleotide STING Agonists to Enhance Cancer Immunotherapy
por: Shae, Daniel, et al.
Publicado: (2019)

Polymersome-mediated cytosolic delivery of cyclic dinucleotide STING agonist enhances tumor immunotherapy
por: Zheng, Huan, et al.
Publicado: (2022)

Amplifying STING Activation by Cyclic Dinucleotide-Manganese Particles for Local and Systemic Cancer Metalloimmunotherapy
por: Sun, Xiaoqi, et al.
Publicado: (2021)

The defense island repertoire of the Escherichia coli pan-genome
por: Hochhauser, Dina, et al.
Publicado: (2023)

Single Nucleotide Polymorphisms of Human STING Can Affect Innate Immune Response to Cyclic Dinucleotides
por: Yi, Guanghui, et al.
Publicado: (2013)

A STING-based fluorescent polarization assay for monitoring activities of cyclic dinucleotide metabolizing enzymes
por: Karanja, Caroline W., et al.
Publicado: (2020)

Bacterial Cyclic Dinucleotides and the cGAS–cGAMP–STING Pathway: A Role in Periodontitis?
por: Elmanfi, Samira, et al.
Publicado: (2021)

Structure of STING bound to c-di-GMP Reveals the Mechanism of Cyclic Dinucleotide Recognition by the Immune System
por: Shu, Chang, et al.
Publicado: (2012)

Modified STING-activating cyclic dinucleotide derivatives significantly enhance the anti-tumor activity of therapeutic vaccines
por: Leong, Meredith, et al.
Publicado: (2013)

Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H
por: Walker, Melissa M., et al.
Publicado: (2020)

Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein
por: Smola, Miroslav, et al.
Publicado: (2021)

Cyclic dinucleotides mediate bacterial immunity by dinucleotide cyclase in Vibrio
por: Lu, Zengzeng, et al.
Publicado: (2022)

A STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells
por: Pollock, Alex J., et al.
Publicado: (2020)

Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists
por: Vavřina, Zdeněk, et al.
Publicado: (2022)

Enzymatic synthesis of cyclic dinucleotide analogs by a promiscuous cyclic-AMP-GMP synthetase and analysis of cyclic dinucleotide responsive riboswitches
por: Launer-Felty, Katherine D, et al.
Publicado: (2018)

Direct activation of STING in the tumor microenvironment with synthetic cyclic dinucleotide derivatives leads to potent and systemic tumor-specific immunity
por: Corrales, Leticia, et al.
Publicado: (2014)

Prokaryotic viperins produce diverse antiviral molecules
por: Bernheim, Aude, et al.
Publicado: (2021)

The Age of Cyclic Dinucleotide Vaccine Adjuvants
por: Gogoi, Himanshu, et al.
Publicado: (2020)

The World of Cyclic Dinucleotides in Bacterial Behavior
por: Aline Dias da, Purificação, et al.
Publicado: (2020)

Supramolecular polymer formation by cyclic dinucleotides and intercalators affects dinucleotide enzymatic processing
por: Nakayama, Shizuka, et al.
Publicado: (2016)

CARD-like domains mediate anti-phage defense in bacterial gasdermin systems
por: Wein, Tanita, et al.
Publicado: (2023)

Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity
por: Hobbs, Samuel J., et al.
Publicado: (2022)

Highly Efficient Preparation of Cyclic Dinucleotides via Engineering of Dinucleotide Cyclases in Escherichia coli
por: Lv, Yun, et al.
Publicado: (2019)

Activation of Gingival Fibroblasts by Bacterial Cyclic Dinucleotides and Lipopolysaccharide
por: Elmanfi, Samira, et al.
Publicado: (2020)

Mass spectrometric characterization of cyclic dinucleotides (CDNs) in vivo
por: Annibal, Andrea, et al.
Publicado: (2021)

Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance
por: Hayoz, Sebastien, et al.
Publicado: (2017)

Quantitation of cyclic dinucleotides by reversed-phase LC-MS/MS
por: Spangler, Christian, et al.
Publicado: (2009)

Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides
por: Elmanfi, Samira, et al.
Publicado: (2018)

SLC19A1 transports immunoreactive cyclic dinucleotides
por: Luteijn, Rutger D., et al.
Publicado: (2019)

The Promise and Challenges of Cyclic Dinucleotides as Molecular Adjuvants for Vaccine Development
por: Yan, Hongbin, et al.
Publicado: (2021)

Chemical Synthesis of the Fluorescent, Cyclic Dinucleotides c(th)GAMP
por: Veth, Simon, et al.
Publicado: (2022)

Biocatalytic Synthesis of Antiviral Nucleosides, Cyclic Dinucleotides, and Oligonucleotide Therapies
por: Van Giesen, Kyle J. D., et al.
Publicado: (2022)

Conserved strategies for pathogen evasion of cGAS–STING immunity
por: Eaglesham, James B, et al.
Publicado: (2020)

Cyclic dinucleotides (CDNs) reversed T cells tolerance in anti-tumor immunotherapy
por: Fu, Juan, et al.
Publicado: (2015)

Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides
por: Cao, Xueli, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_b13u844rqqori8mu8vj9q2sdah