Fruitful Neutralizing Antibody Pipeline Brings Hope To Defeat SARS-Cov-2

With the recent spread of severe acute respiratory syndrome coronavirus (SARS-CoV-2)_ infecting >16 million people worldwide as of 28 July 2020, causing >650 000 deaths, there is a desperate need for therapeutic agents and vaccines. Building on knowledge of previous outbreaks of SARS-CoV-1 and...

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Autores principales: Renn, Alex, Fu, Ying, Hu, Xin, Hall, Matthew D., Simeonov, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published By Elsevier In Association With The International Union Of Pharmacology 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572790/
https://www.ncbi.nlm.nih.gov/pubmed/32829936
http://dx.doi.org/10.1016/j.tips.2020.07.004
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author Renn, Alex
Fu, Ying
Hu, Xin
Hall, Matthew D.
Simeonov, Anton
author_facet Renn, Alex
Fu, Ying
Hu, Xin
Hall, Matthew D.
Simeonov, Anton
author_sort Renn, Alex
collection PubMed
description With the recent spread of severe acute respiratory syndrome coronavirus (SARS-CoV-2)_ infecting >16 million people worldwide as of 28 July 2020, causing >650 000 deaths, there is a desperate need for therapeutic agents and vaccines. Building on knowledge of previous outbreaks of SARS-CoV-1 and Middle East respiratory syndrome (MERS), the development of therapeutic antibodies and vaccines against coronavirus disease 2019 (COVID-19) is taking place at an unprecedented speed. Current efforts towards the development of neutralizing antibodies against COVID-19 are summarized. We also highlight the importance of a fruitful antibody development pipeline to combat the potential escape plans of SARS-CoV-2, including somatic mutations and antibody-dependent enhancement (ADE).
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spelling pubmed-75727902021-01-26 Fruitful Neutralizing Antibody Pipeline Brings Hope To Defeat SARS-Cov-2 Renn, Alex Fu, Ying Hu, Xin Hall, Matthew D. Simeonov, Anton Trends Pharmacol Sci Review With the recent spread of severe acute respiratory syndrome coronavirus (SARS-CoV-2)_ infecting >16 million people worldwide as of 28 July 2020, causing >650 000 deaths, there is a desperate need for therapeutic agents and vaccines. Building on knowledge of previous outbreaks of SARS-CoV-1 and Middle East respiratory syndrome (MERS), the development of therapeutic antibodies and vaccines against coronavirus disease 2019 (COVID-19) is taking place at an unprecedented speed. Current efforts towards the development of neutralizing antibodies against COVID-19 are summarized. We also highlight the importance of a fruitful antibody development pipeline to combat the potential escape plans of SARS-CoV-2, including somatic mutations and antibody-dependent enhancement (ADE). Published By Elsevier In Association With The International Union Of Pharmacology 2020-11 2020-07-31 /pmc/articles/PMC7572790/ /pubmed/32829936 http://dx.doi.org/10.1016/j.tips.2020.07.004 Text en Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Renn, Alex
Fu, Ying
Hu, Xin
Hall, Matthew D.
Simeonov, Anton
Fruitful Neutralizing Antibody Pipeline Brings Hope To Defeat SARS-Cov-2
title Fruitful Neutralizing Antibody Pipeline Brings Hope To Defeat SARS-Cov-2
title_full Fruitful Neutralizing Antibody Pipeline Brings Hope To Defeat SARS-Cov-2
title_fullStr Fruitful Neutralizing Antibody Pipeline Brings Hope To Defeat SARS-Cov-2
title_full_unstemmed Fruitful Neutralizing Antibody Pipeline Brings Hope To Defeat SARS-Cov-2
title_short Fruitful Neutralizing Antibody Pipeline Brings Hope To Defeat SARS-Cov-2
title_sort fruitful neutralizing antibody pipeline brings hope to defeat sars-cov-2
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572790/
https://www.ncbi.nlm.nih.gov/pubmed/32829936
http://dx.doi.org/10.1016/j.tips.2020.07.004
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