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Knockout of miR-21-5p alleviates cartilage matrix degradation by targeting Gdf5 in temporomandibular joint osteoarthritis

AIMS: The study aimed to determine whether the microRNA miR21-5p (MiR21) mediates temporomandibular joint osteoarthritis (TMJ-OA) by targeting growth differentiation factor 5 (Gdf5). METHODS: TMJ-OA was induced in MiR21 knockout (KO) mice and wild-type (WT) mice by a unilateral anterior crossbite (U...

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Detalles Bibliográficos
Autores principales:	Zhang, Aobo, Ma, Shixing, Yuan, Lingyu, Wu, Shichao, Liu, Shaopeng, Wei, Xiang, Chen, Lei, Ma, Chuan, Zhao, Huaqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The British Editorial Society of Bone & Joint Surgery 2020
Materias:	Arthritis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572806/ https://www.ncbi.nlm.nih.gov/pubmed/33231490 http://dx.doi.org/10.1302/2046-3758.910.BJR-2020-0140.R1

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