Cargando…
Target Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer’s Disease
Alzheimer’s disease (AD) is commonly an age-associated dementia with neurodegeneration. The pathogenesis of AD is complex and still remains unclear. The inflammation, amyloid β (Aβ), and neurofibrillary tangles as well misfolded tau protein in the brain may contribute to the occurrence and developme...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572848/ https://www.ncbi.nlm.nih.gov/pubmed/33132894 http://dx.doi.org/10.3389/fnagi.2020.544235 |
_version_ | 1783597361164976128 |
---|---|
author | Zhu, Feiqi Li, Chunrong Chu, Fengna Tian, Xiaoping Zhu, Jie |
author_facet | Zhu, Feiqi Li, Chunrong Chu, Fengna Tian, Xiaoping Zhu, Jie |
author_sort | Zhu, Feiqi |
collection | PubMed |
description | Alzheimer’s disease (AD) is commonly an age-associated dementia with neurodegeneration. The pathogenesis of AD is complex and still remains unclear. The inflammation, amyloid β (Aβ), and neurofibrillary tangles as well misfolded tau protein in the brain may contribute to the occurrence and development of AD. Compared with tau protein, Aβ is less toxic. So far, all efforts made in the treatments of AD with targeting these pathogenic factors were unsuccessful over the past decades. Recently, many studies demonstrated that changes of the intestinal environment and gut microbiota via gut–brain axis pathway can cause neurological disorders, such as AD, which may be involved in the pathogenesis of AD. Thus, remodeling the gut microbiota by various ways to maintain their balance might be a novel therapeutic strategy for AD. In the review article, we analyzed the characteristics of gut microbiota and its dysbiosis in AD and its animal models and investigated the possibility of targeting the gut microbiota in the treatment of the patients with AD in the future. |
format | Online Article Text |
id | pubmed-7572848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75728482020-10-30 Target Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer’s Disease Zhu, Feiqi Li, Chunrong Chu, Fengna Tian, Xiaoping Zhu, Jie Front Aging Neurosci Neuroscience Alzheimer’s disease (AD) is commonly an age-associated dementia with neurodegeneration. The pathogenesis of AD is complex and still remains unclear. The inflammation, amyloid β (Aβ), and neurofibrillary tangles as well misfolded tau protein in the brain may contribute to the occurrence and development of AD. Compared with tau protein, Aβ is less toxic. So far, all efforts made in the treatments of AD with targeting these pathogenic factors were unsuccessful over the past decades. Recently, many studies demonstrated that changes of the intestinal environment and gut microbiota via gut–brain axis pathway can cause neurological disorders, such as AD, which may be involved in the pathogenesis of AD. Thus, remodeling the gut microbiota by various ways to maintain their balance might be a novel therapeutic strategy for AD. In the review article, we analyzed the characteristics of gut microbiota and its dysbiosis in AD and its animal models and investigated the possibility of targeting the gut microbiota in the treatment of the patients with AD in the future. Frontiers Media S.A. 2020-10-06 /pmc/articles/PMC7572848/ /pubmed/33132894 http://dx.doi.org/10.3389/fnagi.2020.544235 Text en Copyright © 2020 Zhu, Li, Chu, Tian and Zhu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Zhu, Feiqi Li, Chunrong Chu, Fengna Tian, Xiaoping Zhu, Jie Target Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer’s Disease |
title | Target Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer’s Disease |
title_full | Target Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer’s Disease |
title_fullStr | Target Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer’s Disease |
title_full_unstemmed | Target Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer’s Disease |
title_short | Target Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer’s Disease |
title_sort | target dysbiosis of gut microbes as a future therapeutic manipulation in alzheimer’s disease |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572848/ https://www.ncbi.nlm.nih.gov/pubmed/33132894 http://dx.doi.org/10.3389/fnagi.2020.544235 |
work_keys_str_mv | AT zhufeiqi targetdysbiosisofgutmicrobesasafuturetherapeuticmanipulationinalzheimersdisease AT lichunrong targetdysbiosisofgutmicrobesasafuturetherapeuticmanipulationinalzheimersdisease AT chufengna targetdysbiosisofgutmicrobesasafuturetherapeuticmanipulationinalzheimersdisease AT tianxiaoping targetdysbiosisofgutmicrobesasafuturetherapeuticmanipulationinalzheimersdisease AT zhujie targetdysbiosisofgutmicrobesasafuturetherapeuticmanipulationinalzheimersdisease |