The Oncometabolite 5′-Deoxy-5′-Methylthioadenosine Blocks Multiple Signaling Pathways of NK Cell Activation

Tumor cells develop various mechanisms to escape immune surveillance. In this context, oncometabolites secreted by tumor cells due to deregulated metabolic pathways, have been in the spotlight of researchers during the last years. 5′-Deoxy-5′-methylthioadenosine (MTA) phosphorylase (MTAP) deficiency...

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Detalles Bibliográficos
Autores principales: Jacobs, Benedikt, Schlögl, Sebastian, Strobl, Carolin Dorothea, Völkl, Simon, Stoll, Andrej, Mougiakakos, Dimitrios, Malmberg, Karl-Johan, Mackensen, Andreas, Aigner, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573074/
https://www.ncbi.nlm.nih.gov/pubmed/33123121
http://dx.doi.org/10.3389/fimmu.2020.02128

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