Evolutionarily Selected Overexpression of the Cytokine BAFF Enhances Mucosal Immune Response Against P. falciparum

We have previously shown that a variant of the TNFSF13B gene that we called BAFF-var increases the production of the cytokine BAFF, upregulating humoral immunity and increasing the risk for certain autoimmune diseases. In addition, genetic population signatures revealed that BAFF-var was evolutionar...

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Detalles Bibliográficos
Autores principales: Lodde, Valeria, Floris, Matteo, Beerman, Isabel, Munk, Rachel, Guha, Rajan, Steri, Maristella, Orrù, Valeria, Abdelmohsen, Kotb, Crompton, Peter D., Gorospe, Myriam, Idda, Maria Laura, Cucca, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573158/
https://www.ncbi.nlm.nih.gov/pubmed/33123155
http://dx.doi.org/10.3389/fimmu.2020.575103

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