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Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery

Protein kinases and GTPases are the two major molecular switches that regulate much of biology, and both of these domains are embedded within the large multi-domain Leucine-Rich Repeat Kinase 2 (LRRK2). Mutations in LRRK2 are the most common cause of familial Parkinson’s disease (PD) and are also im...

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Detalles Bibliográficos
Autores principales:	Taylor, Susan S., Kaila-Sharma, Pallavi, Weng, Jui-Hung, Aoto, Phillip, Schmidt, Sven H., Knapp, Stefan, Mathea, Sebastian, Herberg, Friedrich W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573214/ https://www.ncbi.nlm.nih.gov/pubmed/33122997 http://dx.doi.org/10.3389/fnmol.2020.538219

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