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Upregulation of μ-Opioid Receptor in the Rat Spinal Cord Contributes to the α2-Adrenoceptor Agonist Dexmedetomidine-Induced Attenuation of Chronic Morphine Tolerance in Cancer Pain

BACKGROUND: Sustained morphine treatment for cancer pain has been limited due to analgesic tolerance. Opioid receptor internalization and desensitization mediated by downregulation of mu-opioid receptor (MOR) expression have been confirmed as one of the mechanisms of chronic morphine tolerance. In a...

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Detalles Bibliográficos
Autores principales:	Zhang, Pinyi, Bu, Jianlong, Wu, Xiaohong, Deng, Lin, Chi, Meng, Ma, Chao, Shi, Xiaoding, Wang, Guonian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573317/ https://www.ncbi.nlm.nih.gov/pubmed/33116804 http://dx.doi.org/10.2147/JPR.S274225

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