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Ki67, CD105, and α-SMA Expression Supports Biological Distinctness of Oral Squamous Cell Carcinoma Arising in the Background of Oral Submucous Fibrosis

BACKGROUND: The clinicopathological distinctness of oral squamous cell carcinoma arising in the background of oral submucous fibrosis (OSCC-OSF) is well known; however, the molecular distinctness of this unique OSCC-OSF has not been investigated to date. With this in mind, we compared the expression...

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Autores principales: Gadbail, Amol Ramchandra, Korde, Sheetal, Chaudhary, Minal S, Sarode, Sachin C, Gondivkar, Shailesh M, Dande, Ravi, Tekade, Satyajit Ashok, Yuwanati, Monal, Hande, Alka, Patil, Shankargouda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573415/
https://www.ncbi.nlm.nih.gov/pubmed/32711434
http://dx.doi.org/10.31557/APJCP.2020.21.7.2067
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author Gadbail, Amol Ramchandra
Korde, Sheetal
Chaudhary, Minal S
Sarode, Sachin C
Gondivkar, Shailesh M
Dande, Ravi
Tekade, Satyajit Ashok
Yuwanati, Monal
Hande, Alka
Patil, Shankargouda
author_facet Gadbail, Amol Ramchandra
Korde, Sheetal
Chaudhary, Minal S
Sarode, Sachin C
Gondivkar, Shailesh M
Dande, Ravi
Tekade, Satyajit Ashok
Yuwanati, Monal
Hande, Alka
Patil, Shankargouda
author_sort Gadbail, Amol Ramchandra
collection PubMed
description BACKGROUND: The clinicopathological distinctness of oral squamous cell carcinoma arising in the background of oral submucous fibrosis (OSCC-OSF) is well known; however, the molecular distinctness of this unique OSCC-OSF has not been investigated to date. With this in mind, we compared the expression of Ki67, CD105, and α-SMA between OSCC-OSF and oral squamous cell carcinoma (OSCC). METHODS: Formalin-fixed paraffin-embedded tissues of 105 OSCC-OSF and 112 OSCC cases were subjected to immunohistochemistry for evaluation of Ki67, CD105, and α-SMA expression. RESULTS: Ki67 (labeling index) LI, MVD and α-SMA expression were significantly higher in OSCC compared to OSCC-OSF. Ki67 LI and MVD was significantly higher in OSCC compared to OSCC-OSF in parameters such as well-differentiated, early TNM stage, non-metastatic, and more than 3-year survival. α-SMA expression was significantly higher in OSCC compared to OSCC-OSF in parameters such as moderate differentiation, metastatic lesions, and survival less than 3 years. Ki67 LI, MVD and α-SMA showed significant positive correlation with each other in OSCC and OSCC-OSF. CONCLUSION: Proliferation, neoangiogenesis and myofibroblast differentiation were significantly higher in the OSCC group compared to the OSCC-OSF group. This suggests the biological distinctness of OSCC-OSF, which could help the future development of targeted therapies.
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spelling pubmed-75734152020-10-30 Ki67, CD105, and α-SMA Expression Supports Biological Distinctness of Oral Squamous Cell Carcinoma Arising in the Background of Oral Submucous Fibrosis Gadbail, Amol Ramchandra Korde, Sheetal Chaudhary, Minal S Sarode, Sachin C Gondivkar, Shailesh M Dande, Ravi Tekade, Satyajit Ashok Yuwanati, Monal Hande, Alka Patil, Shankargouda Asian Pac J Cancer Prev Research Article BACKGROUND: The clinicopathological distinctness of oral squamous cell carcinoma arising in the background of oral submucous fibrosis (OSCC-OSF) is well known; however, the molecular distinctness of this unique OSCC-OSF has not been investigated to date. With this in mind, we compared the expression of Ki67, CD105, and α-SMA between OSCC-OSF and oral squamous cell carcinoma (OSCC). METHODS: Formalin-fixed paraffin-embedded tissues of 105 OSCC-OSF and 112 OSCC cases were subjected to immunohistochemistry for evaluation of Ki67, CD105, and α-SMA expression. RESULTS: Ki67 (labeling index) LI, MVD and α-SMA expression were significantly higher in OSCC compared to OSCC-OSF. Ki67 LI and MVD was significantly higher in OSCC compared to OSCC-OSF in parameters such as well-differentiated, early TNM stage, non-metastatic, and more than 3-year survival. α-SMA expression was significantly higher in OSCC compared to OSCC-OSF in parameters such as moderate differentiation, metastatic lesions, and survival less than 3 years. Ki67 LI, MVD and α-SMA showed significant positive correlation with each other in OSCC and OSCC-OSF. CONCLUSION: Proliferation, neoangiogenesis and myofibroblast differentiation were significantly higher in the OSCC group compared to the OSCC-OSF group. This suggests the biological distinctness of OSCC-OSF, which could help the future development of targeted therapies. West Asia Organization for Cancer Prevention 2020-07 /pmc/articles/PMC7573415/ /pubmed/32711434 http://dx.doi.org/10.31557/APJCP.2020.21.7.2067 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gadbail, Amol Ramchandra
Korde, Sheetal
Chaudhary, Minal S
Sarode, Sachin C
Gondivkar, Shailesh M
Dande, Ravi
Tekade, Satyajit Ashok
Yuwanati, Monal
Hande, Alka
Patil, Shankargouda
Ki67, CD105, and α-SMA Expression Supports Biological Distinctness of Oral Squamous Cell Carcinoma Arising in the Background of Oral Submucous Fibrosis
title Ki67, CD105, and α-SMA Expression Supports Biological Distinctness of Oral Squamous Cell Carcinoma Arising in the Background of Oral Submucous Fibrosis
title_full Ki67, CD105, and α-SMA Expression Supports Biological Distinctness of Oral Squamous Cell Carcinoma Arising in the Background of Oral Submucous Fibrosis
title_fullStr Ki67, CD105, and α-SMA Expression Supports Biological Distinctness of Oral Squamous Cell Carcinoma Arising in the Background of Oral Submucous Fibrosis
title_full_unstemmed Ki67, CD105, and α-SMA Expression Supports Biological Distinctness of Oral Squamous Cell Carcinoma Arising in the Background of Oral Submucous Fibrosis
title_short Ki67, CD105, and α-SMA Expression Supports Biological Distinctness of Oral Squamous Cell Carcinoma Arising in the Background of Oral Submucous Fibrosis
title_sort ki67, cd105, and α-sma expression supports biological distinctness of oral squamous cell carcinoma arising in the background of oral submucous fibrosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573415/
https://www.ncbi.nlm.nih.gov/pubmed/32711434
http://dx.doi.org/10.31557/APJCP.2020.21.7.2067
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