Amelioration of Cisplatin-Induced Ototoxicity in Rats by L-arginine: The Role of Nitric Oxide, Transforming Growth Factor Beta 1 and Nrf2/HO-1 Pathway

BACKGROUND: Cisplatin is an alkylating agent that inhibits DNA replication and interferes with proliferation of cancer cells. However, the major limiting factor for its use is the possible development of adverse effects, including ototoxicity. Up till now, the mechanisms of this ototoxicity remain p...

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Detalles Bibliográficos
Autores principales: Estfanous, Remon S, Elseady, Walaa S, Kabel, Ahmed M, Abd Ellatif, Rasha A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573422/
https://www.ncbi.nlm.nih.gov/pubmed/32711445
http://dx.doi.org/10.31557/APJCP.2020.21.7.2155

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