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Loss of Fbxw7 triggers mammary tumorigenesis associated with E2F/c-Myc activation and Trp53 mutation

Fbw7 is a tumor suppressor that regulates the degradation of oncogenic substrates such as c-Jun, c-Myc, Notch1 intracellular domain (ICD), and cyclin E by functioning as the substrate recognition protein in the Skp1-Cullin-F-box (SCF) ubiquitin ligase complex. Consequently, low expression or loss of...

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Detalles Bibliográficos
Autores principales:	Meyer, Alison E., Furumo, Quinlan, Stelloh, Cary, Minella, Alex C., Rao, Sridhar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573506/ https://www.ncbi.nlm.nih.gov/pubmed/33070870 http://dx.doi.org/10.1016/j.neo.2020.07.001

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