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Modulatory effects of dynamic fMRI-based neurofeedback on emotion regulation networks in adolescent females
Research has shown that difficulties with emotion regulation abilities in childhood and adolescence increase the risk for developing symptoms of mental disorders, e.g anxiety. We investigated whether functional magnetic resonance imaging (fMRI)-based neurofeedback (NF) can modulate brain networks su...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academic Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573536/ https://www.ncbi.nlm.nih.gov/pubmed/32574803 http://dx.doi.org/10.1016/j.neuroimage.2020.117053 |
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author | Zich, Catharina Johnstone, Nicola Lührs, Michael Lisk, Stephen Haller, Simone PW. Lipp, Annalisa Lau, Jennifer YF. Kadosh, Kathrin Cohen |
author_facet | Zich, Catharina Johnstone, Nicola Lührs, Michael Lisk, Stephen Haller, Simone PW. Lipp, Annalisa Lau, Jennifer YF. Kadosh, Kathrin Cohen |
author_sort | Zich, Catharina |
collection | PubMed |
description | Research has shown that difficulties with emotion regulation abilities in childhood and adolescence increase the risk for developing symptoms of mental disorders, e.g anxiety. We investigated whether functional magnetic resonance imaging (fMRI)-based neurofeedback (NF) can modulate brain networks supporting emotion regulation abilities in adolescent females. We performed three experiments (Experiment 1: N = 18; Experiment 2: N = 30; Experiment 3: N = 20). We first compared different NF implementations regarding their effectiveness of modulating prefrontal cortex (PFC)-amygdala functional connectivity (fc). Further we assessed the effects of fc-NF on neural measures, emotional/metacognitive measures and their associations. Finally, we probed the mechanism underlying fc-NF by examining concentrations of inhibitory and excitatory neurotransmitters. Results showed that NF implementations differentially modulate PFC-amygdala fc. Using the most effective NF implementation we observed important relationships between neural and emotional/metacognitive measures, such as practice-related change in fc was related with change in thought control ability. Further, we found that the relationship between state anxiety prior to the MRI session and the effect of fc-NF was moderated by GABA concentrations in the PFC and anterior cingulate cortex. To conclude, we were able to show that fc-NF can be used in adolescent females to shape neural and emotional/metacognitive measures underlying emotion regulation. We further show that neurotransmitter concentrations moderate fc–NF–effects. |
format | Online Article Text |
id | pubmed-7573536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Academic Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-75735362020-10-23 Modulatory effects of dynamic fMRI-based neurofeedback on emotion regulation networks in adolescent females Zich, Catharina Johnstone, Nicola Lührs, Michael Lisk, Stephen Haller, Simone PW. Lipp, Annalisa Lau, Jennifer YF. Kadosh, Kathrin Cohen Neuroimage Article Research has shown that difficulties with emotion regulation abilities in childhood and adolescence increase the risk for developing symptoms of mental disorders, e.g anxiety. We investigated whether functional magnetic resonance imaging (fMRI)-based neurofeedback (NF) can modulate brain networks supporting emotion regulation abilities in adolescent females. We performed three experiments (Experiment 1: N = 18; Experiment 2: N = 30; Experiment 3: N = 20). We first compared different NF implementations regarding their effectiveness of modulating prefrontal cortex (PFC)-amygdala functional connectivity (fc). Further we assessed the effects of fc-NF on neural measures, emotional/metacognitive measures and their associations. Finally, we probed the mechanism underlying fc-NF by examining concentrations of inhibitory and excitatory neurotransmitters. Results showed that NF implementations differentially modulate PFC-amygdala fc. Using the most effective NF implementation we observed important relationships between neural and emotional/metacognitive measures, such as practice-related change in fc was related with change in thought control ability. Further, we found that the relationship between state anxiety prior to the MRI session and the effect of fc-NF was moderated by GABA concentrations in the PFC and anterior cingulate cortex. To conclude, we were able to show that fc-NF can be used in adolescent females to shape neural and emotional/metacognitive measures underlying emotion regulation. We further show that neurotransmitter concentrations moderate fc–NF–effects. Academic Press 2020-10-15 /pmc/articles/PMC7573536/ /pubmed/32574803 http://dx.doi.org/10.1016/j.neuroimage.2020.117053 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zich, Catharina Johnstone, Nicola Lührs, Michael Lisk, Stephen Haller, Simone PW. Lipp, Annalisa Lau, Jennifer YF. Kadosh, Kathrin Cohen Modulatory effects of dynamic fMRI-based neurofeedback on emotion regulation networks in adolescent females |
title | Modulatory effects of dynamic fMRI-based neurofeedback on emotion regulation networks in adolescent females |
title_full | Modulatory effects of dynamic fMRI-based neurofeedback on emotion regulation networks in adolescent females |
title_fullStr | Modulatory effects of dynamic fMRI-based neurofeedback on emotion regulation networks in adolescent females |
title_full_unstemmed | Modulatory effects of dynamic fMRI-based neurofeedback on emotion regulation networks in adolescent females |
title_short | Modulatory effects of dynamic fMRI-based neurofeedback on emotion regulation networks in adolescent females |
title_sort | modulatory effects of dynamic fmri-based neurofeedback on emotion regulation networks in adolescent females |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573536/ https://www.ncbi.nlm.nih.gov/pubmed/32574803 http://dx.doi.org/10.1016/j.neuroimage.2020.117053 |
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