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Intrinsic ADE: The Dark Side of Antibody Dependent Enhancement During Dengue Infection
Dengue fever is an Aedes mosquito-borne illness caused by any one of the four different dengue virus (DENV) serotypes (1–4) and manifests in the form of symptoms ranging from mild or asymptomatic to severe disease with vascular leakage, leading to shock, and viral hemorrhagic syndrome. Increased ris...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573563/ https://www.ncbi.nlm.nih.gov/pubmed/33123500 http://dx.doi.org/10.3389/fcimb.2020.580096 |
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author | Narayan, Rohan Tripathi, Shashank |
author_facet | Narayan, Rohan Tripathi, Shashank |
author_sort | Narayan, Rohan |
collection | PubMed |
description | Dengue fever is an Aedes mosquito-borne illness caused by any one of the four different dengue virus (DENV) serotypes (1–4) and manifests in the form of symptoms ranging from mild or asymptomatic to severe disease with vascular leakage, leading to shock, and viral hemorrhagic syndrome. Increased risk of severe disease occurs during secondary infection with a virus serotype distinct from that of prior dengue infection. This occurs by antibody dependent enhancement (ADE) of infection, wherein sub-neutralizing antibodies against the virus particles opsonize dengue virus entry via formation of immune complexes that interact with fragment crystallizable gamma receptors (FcγR) on monocytes, dendritic cells, and macrophages. The ADE phenomenon has two components: Extrinsic and Intrinsic ADE. While extrinsic ADE contributes to enhanced virus entry, intrinsic ADE results in heightened virus production by inhibition of type1 interferon and activation of interleukin-10 biosynthesis, thereby favoring a Th2 type immune response. Intrinsic ADE has greater contribution in enhancing Dengue replication as compared to extrinsic ADE. Detailed elucidation of intrinsic ADE during secondary dengue infection can increase our understanding of DENV-pathogenesis and aid in the development of host-targeting antivirals. Here we review literature focusing on intrinsic factors contributing to severe dengue pathology and suggest possible avenues for further research. |
format | Online Article Text |
id | pubmed-7573563 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75735632020-10-28 Intrinsic ADE: The Dark Side of Antibody Dependent Enhancement During Dengue Infection Narayan, Rohan Tripathi, Shashank Front Cell Infect Microbiol Cellular and Infection Microbiology Dengue fever is an Aedes mosquito-borne illness caused by any one of the four different dengue virus (DENV) serotypes (1–4) and manifests in the form of symptoms ranging from mild or asymptomatic to severe disease with vascular leakage, leading to shock, and viral hemorrhagic syndrome. Increased risk of severe disease occurs during secondary infection with a virus serotype distinct from that of prior dengue infection. This occurs by antibody dependent enhancement (ADE) of infection, wherein sub-neutralizing antibodies against the virus particles opsonize dengue virus entry via formation of immune complexes that interact with fragment crystallizable gamma receptors (FcγR) on monocytes, dendritic cells, and macrophages. The ADE phenomenon has two components: Extrinsic and Intrinsic ADE. While extrinsic ADE contributes to enhanced virus entry, intrinsic ADE results in heightened virus production by inhibition of type1 interferon and activation of interleukin-10 biosynthesis, thereby favoring a Th2 type immune response. Intrinsic ADE has greater contribution in enhancing Dengue replication as compared to extrinsic ADE. Detailed elucidation of intrinsic ADE during secondary dengue infection can increase our understanding of DENV-pathogenesis and aid in the development of host-targeting antivirals. Here we review literature focusing on intrinsic factors contributing to severe dengue pathology and suggest possible avenues for further research. Frontiers Media S.A. 2020-10-02 /pmc/articles/PMC7573563/ /pubmed/33123500 http://dx.doi.org/10.3389/fcimb.2020.580096 Text en Copyright © 2020 Narayan and Tripathi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Narayan, Rohan Tripathi, Shashank Intrinsic ADE: The Dark Side of Antibody Dependent Enhancement During Dengue Infection |
title | Intrinsic ADE: The Dark Side of Antibody Dependent Enhancement During Dengue Infection |
title_full | Intrinsic ADE: The Dark Side of Antibody Dependent Enhancement During Dengue Infection |
title_fullStr | Intrinsic ADE: The Dark Side of Antibody Dependent Enhancement During Dengue Infection |
title_full_unstemmed | Intrinsic ADE: The Dark Side of Antibody Dependent Enhancement During Dengue Infection |
title_short | Intrinsic ADE: The Dark Side of Antibody Dependent Enhancement During Dengue Infection |
title_sort | intrinsic ade: the dark side of antibody dependent enhancement during dengue infection |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573563/ https://www.ncbi.nlm.nih.gov/pubmed/33123500 http://dx.doi.org/10.3389/fcimb.2020.580096 |
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