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The Sensing Liver: Localization and Ligands for Hepatic Murine Olfactory and Taste Receptors
Sensory receptors, including olfactory receptors (ORs), taste receptors (TRs), and opsins (Opns) have recently been found in a variety of non-sensory tissues where they have distinct physiological functions. As G protein-coupled receptors (GPCRs), these proteins can serve as important chemosensors b...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573564/ https://www.ncbi.nlm.nih.gov/pubmed/33123030 http://dx.doi.org/10.3389/fphys.2020.574082 |
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author | Kurtz, Ryan Steinberg, Lily G. Betcher, Madison Fowler, Dalton Shepard, Blythe D. |
author_facet | Kurtz, Ryan Steinberg, Lily G. Betcher, Madison Fowler, Dalton Shepard, Blythe D. |
author_sort | Kurtz, Ryan |
collection | PubMed |
description | Sensory receptors, including olfactory receptors (ORs), taste receptors (TRs), and opsins (Opns) have recently been found in a variety of non-sensory tissues where they have distinct physiological functions. As G protein-coupled receptors (GPCRs), these proteins can serve as important chemosensors by sensing and interpreting chemical cues in the environment. We reasoned that the liver, the largest metabolic organ in the body, is primed to take advantage of some of these sensory receptors in order to sense and regulate blood content and metabolism. In this study, we report the expression of novel hepatic sensory receptors – including 7 ORs, 6 bitter TRs, and 1 Opn – identified through a systematic molecular biology screening approach. We further determined that several of these receptors are expressed within hepatocytes, the parenchymal cells of the liver. Finally, we uncovered several agonists of the previously orphaned hepatic ORs. These compounds fall under two classes: methylpyrazines and monoterpenes. In particular, the latter chemicals are plant and fungal-derived compounds with known hepatic protective effects. Collectively, this study sheds light on the chemosensory functions of the liver and unveils potentially important regulators of hepatic homeostasis. |
format | Online Article Text |
id | pubmed-7573564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75735642020-10-28 The Sensing Liver: Localization and Ligands for Hepatic Murine Olfactory and Taste Receptors Kurtz, Ryan Steinberg, Lily G. Betcher, Madison Fowler, Dalton Shepard, Blythe D. Front Physiol Physiology Sensory receptors, including olfactory receptors (ORs), taste receptors (TRs), and opsins (Opns) have recently been found in a variety of non-sensory tissues where they have distinct physiological functions. As G protein-coupled receptors (GPCRs), these proteins can serve as important chemosensors by sensing and interpreting chemical cues in the environment. We reasoned that the liver, the largest metabolic organ in the body, is primed to take advantage of some of these sensory receptors in order to sense and regulate blood content and metabolism. In this study, we report the expression of novel hepatic sensory receptors – including 7 ORs, 6 bitter TRs, and 1 Opn – identified through a systematic molecular biology screening approach. We further determined that several of these receptors are expressed within hepatocytes, the parenchymal cells of the liver. Finally, we uncovered several agonists of the previously orphaned hepatic ORs. These compounds fall under two classes: methylpyrazines and monoterpenes. In particular, the latter chemicals are plant and fungal-derived compounds with known hepatic protective effects. Collectively, this study sheds light on the chemosensory functions of the liver and unveils potentially important regulators of hepatic homeostasis. Frontiers Media S.A. 2020-10-06 /pmc/articles/PMC7573564/ /pubmed/33123030 http://dx.doi.org/10.3389/fphys.2020.574082 Text en Copyright © 2020 Kurtz, Steinberg, Betcher, Fowler and Shepard. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Kurtz, Ryan Steinberg, Lily G. Betcher, Madison Fowler, Dalton Shepard, Blythe D. The Sensing Liver: Localization and Ligands for Hepatic Murine Olfactory and Taste Receptors |
title | The Sensing Liver: Localization and Ligands for Hepatic Murine Olfactory and Taste Receptors |
title_full | The Sensing Liver: Localization and Ligands for Hepatic Murine Olfactory and Taste Receptors |
title_fullStr | The Sensing Liver: Localization and Ligands for Hepatic Murine Olfactory and Taste Receptors |
title_full_unstemmed | The Sensing Liver: Localization and Ligands for Hepatic Murine Olfactory and Taste Receptors |
title_short | The Sensing Liver: Localization and Ligands for Hepatic Murine Olfactory and Taste Receptors |
title_sort | sensing liver: localization and ligands for hepatic murine olfactory and taste receptors |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573564/ https://www.ncbi.nlm.nih.gov/pubmed/33123030 http://dx.doi.org/10.3389/fphys.2020.574082 |
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