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The mouse model of fragile X syndrome exhibits deficits in contagious itch behavior

Individuals with autism spectrum disorders (ASDs) imitate observed behavior less than age-matched and typically developing peers, resulting in deterred learning ability and social interaction. However, this deficit lacks preclinical assessment tools. A previous study has shown that mice exhibit cont...

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Autores principales: Gonzales-Rojas, Rodrigo, Rana, Amtul-Noor, Mason, Peter, Renfro, Christopher, Annaluru, Vallabhi, Panda, Shree, Lee, Hye Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573600/
https://www.ncbi.nlm.nih.gov/pubmed/33077777
http://dx.doi.org/10.1038/s41598-020-72891-x
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author Gonzales-Rojas, Rodrigo
Rana, Amtul-Noor
Mason, Peter
Renfro, Christopher
Annaluru, Vallabhi
Panda, Shree
Lee, Hye Young
author_facet Gonzales-Rojas, Rodrigo
Rana, Amtul-Noor
Mason, Peter
Renfro, Christopher
Annaluru, Vallabhi
Panda, Shree
Lee, Hye Young
author_sort Gonzales-Rojas, Rodrigo
collection PubMed
description Individuals with autism spectrum disorders (ASDs) imitate observed behavior less than age-matched and typically developing peers, resulting in deterred learning ability and social interaction. However, this deficit lacks preclinical assessment tools. A previous study has shown that mice exhibit contagious itch behavior while viewing a scratching demonstrator mouse, as opposed to an ambulating demonstrator mouse, but whether autism mouse models imitate observed scratching behavior remains unknown. Here, we investigated contagious itch behavior in the mouse model of fragile X syndrome (FXS), a common form of inherited intellectual disabilities with a high risk for ASDs. We found that the mouse model of FXS shows deficits in contagious itch behavior. Our findings can be used as a new preclinical assessment tool for measuring imitative deficits in the study of neurodevelopmental disorders including FXS.
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spelling pubmed-75736002020-10-21 The mouse model of fragile X syndrome exhibits deficits in contagious itch behavior Gonzales-Rojas, Rodrigo Rana, Amtul-Noor Mason, Peter Renfro, Christopher Annaluru, Vallabhi Panda, Shree Lee, Hye Young Sci Rep Article Individuals with autism spectrum disorders (ASDs) imitate observed behavior less than age-matched and typically developing peers, resulting in deterred learning ability and social interaction. However, this deficit lacks preclinical assessment tools. A previous study has shown that mice exhibit contagious itch behavior while viewing a scratching demonstrator mouse, as opposed to an ambulating demonstrator mouse, but whether autism mouse models imitate observed scratching behavior remains unknown. Here, we investigated contagious itch behavior in the mouse model of fragile X syndrome (FXS), a common form of inherited intellectual disabilities with a high risk for ASDs. We found that the mouse model of FXS shows deficits in contagious itch behavior. Our findings can be used as a new preclinical assessment tool for measuring imitative deficits in the study of neurodevelopmental disorders including FXS. Nature Publishing Group UK 2020-10-19 /pmc/articles/PMC7573600/ /pubmed/33077777 http://dx.doi.org/10.1038/s41598-020-72891-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Gonzales-Rojas, Rodrigo
Rana, Amtul-Noor
Mason, Peter
Renfro, Christopher
Annaluru, Vallabhi
Panda, Shree
Lee, Hye Young
The mouse model of fragile X syndrome exhibits deficits in contagious itch behavior
title The mouse model of fragile X syndrome exhibits deficits in contagious itch behavior
title_full The mouse model of fragile X syndrome exhibits deficits in contagious itch behavior
title_fullStr The mouse model of fragile X syndrome exhibits deficits in contagious itch behavior
title_full_unstemmed The mouse model of fragile X syndrome exhibits deficits in contagious itch behavior
title_short The mouse model of fragile X syndrome exhibits deficits in contagious itch behavior
title_sort mouse model of fragile x syndrome exhibits deficits in contagious itch behavior
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573600/
https://www.ncbi.nlm.nih.gov/pubmed/33077777
http://dx.doi.org/10.1038/s41598-020-72891-x
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