Tubulocystic renal cell carcinoma with poorly differentiated foci and loss of fumarate hydratase: A case report

Tubulocystic renal cell carcinoma (RCC) is one of the newly recognized subtypes of RCC. It has a unique cystic morphology and indolent behavior. During the last decade, few studies have been published describing tubulocystic RCC with poorly differentiated foci. A subset of these cases are associated...

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Detalles Bibliográficos
Autores principales: Al-Hussain, Turki O., Alahmadi, Bushra, Junejo, Noor Nabi, Alshammari, Kawther, Bakshi, Nasir, Alzahrani, Hassan Messfer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573761/
https://www.ncbi.nlm.nih.gov/pubmed/33101988
http://dx.doi.org/10.1016/j.eucr.2020.101236
Descripción
Sumario:Tubulocystic renal cell carcinoma (RCC) is one of the newly recognized subtypes of RCC. It has a unique cystic morphology and indolent behavior. During the last decade, few studies have been published describing tubulocystic RCC with poorly differentiated foci. A subset of these cases are associated with loss of fumarate hydratase which is a characteristic feature of hereditary leiomyomatosis and renal cell carcinoma-associated RCC. However, these two entities represent two distinct subtypes of RCC in the recent WHO Classification of kidney tumors. Herein, we are describing a rare case of tubulocystic renal cell carcinoma with poorly differentiated foci and loss of fumarate hydratase.

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