Cargando…

Adverse Neurological Effects of Short-Term Sleep Deprivation in Aging Mice Are Prevented by SS31 Peptide

Sleep deprivation is a potent stress factor that disrupts regulatory pathways in the brain resulting in cognitive dysfunction and increased risk of neurodegenerative disease with increasing age. Prevention of the adverse effects of sleep deprivation could be beneficial in older individuals by restor...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Jinzi, Dou, Yan, Ladiges, Warren C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573804/
https://www.ncbi.nlm.nih.gov/pubmed/33089207
http://dx.doi.org/10.3390/clockssleep2030024
_version_ 1783597514356686848
author Wu, Jinzi
Dou, Yan
Ladiges, Warren C.
author_facet Wu, Jinzi
Dou, Yan
Ladiges, Warren C.
author_sort Wu, Jinzi
collection PubMed
description Sleep deprivation is a potent stress factor that disrupts regulatory pathways in the brain resulting in cognitive dysfunction and increased risk of neurodegenerative disease with increasing age. Prevention of the adverse effects of sleep deprivation could be beneficial in older individuals by restoring healthy brain function. We report here on the ability of SS31, a mitochondrial specific peptide, to attenuate the negative neurological effects of short-term sleep deprivation in aging mice. C57BL/6 female mice, 20 months old, were subcutaneously injected with SS31 (3 mg/kg) or saline daily for four days. Sleep deprivation was 4 h daily for the last two days of SS31 treatment. Mice were immediately tested for learning ability followed by collection of brain and other tissues. In sleep deprived mice treated with SS31, learning impairment was prevented, brain mitochondrial ATP levels and synaptic plasticity regulatory proteins were restored, and reactive oxygen species (ROS) and inflammatory cytokines levels were decreased in the hippocampus. This observation suggests possible therapeutic benefits of SS31 for alleviating adverse neurological effects of short-term sleep loss.
format Online
Article
Text
id pubmed-7573804
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-75738042020-10-20 Adverse Neurological Effects of Short-Term Sleep Deprivation in Aging Mice Are Prevented by SS31 Peptide Wu, Jinzi Dou, Yan Ladiges, Warren C. Clocks Sleep Article Sleep deprivation is a potent stress factor that disrupts regulatory pathways in the brain resulting in cognitive dysfunction and increased risk of neurodegenerative disease with increasing age. Prevention of the adverse effects of sleep deprivation could be beneficial in older individuals by restoring healthy brain function. We report here on the ability of SS31, a mitochondrial specific peptide, to attenuate the negative neurological effects of short-term sleep deprivation in aging mice. C57BL/6 female mice, 20 months old, were subcutaneously injected with SS31 (3 mg/kg) or saline daily for four days. Sleep deprivation was 4 h daily for the last two days of SS31 treatment. Mice were immediately tested for learning ability followed by collection of brain and other tissues. In sleep deprived mice treated with SS31, learning impairment was prevented, brain mitochondrial ATP levels and synaptic plasticity regulatory proteins were restored, and reactive oxygen species (ROS) and inflammatory cytokines levels were decreased in the hippocampus. This observation suggests possible therapeutic benefits of SS31 for alleviating adverse neurological effects of short-term sleep loss. MDPI 2020-08-06 /pmc/articles/PMC7573804/ /pubmed/33089207 http://dx.doi.org/10.3390/clockssleep2030024 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Jinzi
Dou, Yan
Ladiges, Warren C.
Adverse Neurological Effects of Short-Term Sleep Deprivation in Aging Mice Are Prevented by SS31 Peptide
title Adverse Neurological Effects of Short-Term Sleep Deprivation in Aging Mice Are Prevented by SS31 Peptide
title_full Adverse Neurological Effects of Short-Term Sleep Deprivation in Aging Mice Are Prevented by SS31 Peptide
title_fullStr Adverse Neurological Effects of Short-Term Sleep Deprivation in Aging Mice Are Prevented by SS31 Peptide
title_full_unstemmed Adverse Neurological Effects of Short-Term Sleep Deprivation in Aging Mice Are Prevented by SS31 Peptide
title_short Adverse Neurological Effects of Short-Term Sleep Deprivation in Aging Mice Are Prevented by SS31 Peptide
title_sort adverse neurological effects of short-term sleep deprivation in aging mice are prevented by ss31 peptide
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573804/
https://www.ncbi.nlm.nih.gov/pubmed/33089207
http://dx.doi.org/10.3390/clockssleep2030024
work_keys_str_mv AT wujinzi adverseneurologicaleffectsofshorttermsleepdeprivationinagingmicearepreventedbyss31peptide
AT douyan adverseneurologicaleffectsofshorttermsleepdeprivationinagingmicearepreventedbyss31peptide
AT ladigeswarrenc adverseneurologicaleffectsofshorttermsleepdeprivationinagingmicearepreventedbyss31peptide