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Survival of recombinant monoclonal and naturally-occurring human milk immunoglobulins A and G specific to respiratory syncytial virus F protein across simulated human infant gastrointestinal digestion

To help rationally design an antibody for oral administration, we examined how different isotypes (IgG, IgA and sIgA) with the same variable sequence affect antibody stability across digestion. We compared the degradation of recombinant palivizumab (IgG1), and recombinant IgA and sIgA versions of pa...

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Detalles Bibliográficos
Autores principales:	Lueangsakulthai, Jiraporn, Sah, Baidya Nath P., Scottoline, Brian P., Dallas, David C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573813/ https://www.ncbi.nlm.nih.gov/pubmed/33101461 http://dx.doi.org/10.1016/j.jff.2020.104115

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