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A Time Frame for Testing Negative for SARS-COV2 in People with Obesity
OBJECTIVE: Obesity is a major risk factor for becoming seriously ill with the 2019 novel coronavirus (COVID-19). One difficulty faced by clinicians and by patients is the unknown time frame of hospitalization until discharge of symptomatic patients. METHODS: We followed 34 patients with laboratory-c...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573914/ https://www.ncbi.nlm.nih.gov/pubmed/32992323 http://dx.doi.org/10.1159/000511738 |
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author | Dicker, Dror Lev, Shaul Gottesman, Tamar Kournos, Tatiana Dotan, Maya Ashorov, Nina Marcoviciu, Dana Golan, Rachel |
author_facet | Dicker, Dror Lev, Shaul Gottesman, Tamar Kournos, Tatiana Dotan, Maya Ashorov, Nina Marcoviciu, Dana Golan, Rachel |
author_sort | Dicker, Dror |
collection | PubMed |
description | OBJECTIVE: Obesity is a major risk factor for becoming seriously ill with the 2019 novel coronavirus (COVID-19). One difficulty faced by clinicians and by patients is the unknown time frame of hospitalization until discharge of symptomatic patients. METHODS: We followed 34 patients with laboratory-confirmed COVID-19 infection who recovered from the infection. All diagnoses were given using semi-quantitative RT-PCR on nasopharyngeal swabs. Envelope protein gene (E), RNA-dependent RNA polymerase gene (RdRP), and nucleocapsid gene (N) were measured by RT-PCR. Weight was measured and height was self-reported. RESULTS: Mean ± SD age was 51.8 ± 16.7 years. Mean ± SD body mass index (BMI) was 27.4 ± 4.7 kg/m<sup>2</sup>. 26% (9/34) had obesity, with BMI above 30 kg/m<sup>2</sup>. Fifteen patients had BMI between 25 and 29.9 kg/m<sup>2</sup>. The mean length of hospital stay was longer for those with a BMI >25 kg/m<sup>2</sup> (n = 24) than for those with a normal BMI (19.2 vs. 16.0 days, p = 0.08). Comparing people with obesity (BMI >30 kg/m<sup>2</sup> or above) to those without obesity, the difference was larger (20.6 vs. 16.0 days, p = 0.06). A trend for correlation between body weight and the time to negative detection of RdRp gene was found (r = 0.33, p = 0.09). CONCLUSIONS: Our results highlight the need for priority of early detection and testing, and early therapy for people with obesity and COVID-19 infections. |
format | Online Article Text |
id | pubmed-7573914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-75739142020-11-27 A Time Frame for Testing Negative for SARS-COV2 in People with Obesity Dicker, Dror Lev, Shaul Gottesman, Tamar Kournos, Tatiana Dotan, Maya Ashorov, Nina Marcoviciu, Dana Golan, Rachel Obes Facts Research Article OBJECTIVE: Obesity is a major risk factor for becoming seriously ill with the 2019 novel coronavirus (COVID-19). One difficulty faced by clinicians and by patients is the unknown time frame of hospitalization until discharge of symptomatic patients. METHODS: We followed 34 patients with laboratory-confirmed COVID-19 infection who recovered from the infection. All diagnoses were given using semi-quantitative RT-PCR on nasopharyngeal swabs. Envelope protein gene (E), RNA-dependent RNA polymerase gene (RdRP), and nucleocapsid gene (N) were measured by RT-PCR. Weight was measured and height was self-reported. RESULTS: Mean ± SD age was 51.8 ± 16.7 years. Mean ± SD body mass index (BMI) was 27.4 ± 4.7 kg/m<sup>2</sup>. 26% (9/34) had obesity, with BMI above 30 kg/m<sup>2</sup>. Fifteen patients had BMI between 25 and 29.9 kg/m<sup>2</sup>. The mean length of hospital stay was longer for those with a BMI >25 kg/m<sup>2</sup> (n = 24) than for those with a normal BMI (19.2 vs. 16.0 days, p = 0.08). Comparing people with obesity (BMI >30 kg/m<sup>2</sup> or above) to those without obesity, the difference was larger (20.6 vs. 16.0 days, p = 0.06). A trend for correlation between body weight and the time to negative detection of RdRp gene was found (r = 0.33, p = 0.09). CONCLUSIONS: Our results highlight the need for priority of early detection and testing, and early therapy for people with obesity and COVID-19 infections. S. Karger AG 2020-10 2020-09-29 /pmc/articles/PMC7573914/ /pubmed/32992323 http://dx.doi.org/10.1159/000511738 Text en Copyright © 2020 by S. Karger AG, Basel |
spellingShingle | Research Article Dicker, Dror Lev, Shaul Gottesman, Tamar Kournos, Tatiana Dotan, Maya Ashorov, Nina Marcoviciu, Dana Golan, Rachel A Time Frame for Testing Negative for SARS-COV2 in People with Obesity |
title | A Time Frame for Testing Negative for SARS-COV2 in People with Obesity |
title_full | A Time Frame for Testing Negative for SARS-COV2 in People with Obesity |
title_fullStr | A Time Frame for Testing Negative for SARS-COV2 in People with Obesity |
title_full_unstemmed | A Time Frame for Testing Negative for SARS-COV2 in People with Obesity |
title_short | A Time Frame for Testing Negative for SARS-COV2 in People with Obesity |
title_sort | time frame for testing negative for sars-cov2 in people with obesity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573914/ https://www.ncbi.nlm.nih.gov/pubmed/32992323 http://dx.doi.org/10.1159/000511738 |
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