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Respiratory and cardiovascular effects of COVID-19 infection and their management

The COVID-19 epidemic has put an enormous burden on the health-care system and the economy. The virus has very high infectivity and is crippling in patients developing severe disease. The disease caused by this infective agent, a novel RNA coronavirus (SARS-CoV-2), was named by the World Health Orga...

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Autor principal: Kapoor, Mukul Chandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574017/
https://www.ncbi.nlm.nih.gov/pubmed/33100642
http://dx.doi.org/10.4103/joacp.JOACP_242_20
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author Kapoor, Mukul Chandra
author_facet Kapoor, Mukul Chandra
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description The COVID-19 epidemic has put an enormous burden on the health-care system and the economy. The virus has very high infectivity and is crippling in patients developing severe disease. The disease caused by this infective agent, a novel RNA coronavirus (SARS-CoV-2), was named by the World Health Organization as COVID-19. SARS-CoV-2 usually enters the human body from the respiratory tract and gradually causes systemic disease. The disease is mild in 81% and severe in the balance. The virus causes multiorgan damage and primarily damages airway epithelium, small intestine epithelium, and vascular endothelium, which are organs with high angiotensin-converting enzyme (angiotensin-converting enzyme-2 [ACE2] expression). The most affected organ is the lungs, and the cardiovascular system follows it closely. Symptomatic hypoxic patients are initially treated with oxygen supplementation, but those with severe hypoxia need mechanical ventilation support. Patients with COVID-19 infection present as two phenotypes. The ventilation strategy should be based on the phenotype. The disease causes major hemodynamic disturbances in its invasion of the cardiovascular system. Strict personal protection protocols are needed to ensure the safety of health-care workers and nosocomial spread.
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spelling pubmed-75740172020-10-22 Respiratory and cardiovascular effects of COVID-19 infection and their management Kapoor, Mukul Chandra J Anaesthesiol Clin Pharmacol Review Article The COVID-19 epidemic has put an enormous burden on the health-care system and the economy. The virus has very high infectivity and is crippling in patients developing severe disease. The disease caused by this infective agent, a novel RNA coronavirus (SARS-CoV-2), was named by the World Health Organization as COVID-19. SARS-CoV-2 usually enters the human body from the respiratory tract and gradually causes systemic disease. The disease is mild in 81% and severe in the balance. The virus causes multiorgan damage and primarily damages airway epithelium, small intestine epithelium, and vascular endothelium, which are organs with high angiotensin-converting enzyme (angiotensin-converting enzyme-2 [ACE2] expression). The most affected organ is the lungs, and the cardiovascular system follows it closely. Symptomatic hypoxic patients are initially treated with oxygen supplementation, but those with severe hypoxia need mechanical ventilation support. Patients with COVID-19 infection present as two phenotypes. The ventilation strategy should be based on the phenotype. The disease causes major hemodynamic disturbances in its invasion of the cardiovascular system. Strict personal protection protocols are needed to ensure the safety of health-care workers and nosocomial spread. Wolters Kluwer - Medknow 2020-08 2020-07-24 /pmc/articles/PMC7574017/ /pubmed/33100642 http://dx.doi.org/10.4103/joacp.JOACP_242_20 Text en Copyright: © 2020 Journal of Anaesthesiology Clinical Pharmacology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Kapoor, Mukul Chandra
Respiratory and cardiovascular effects of COVID-19 infection and their management
title Respiratory and cardiovascular effects of COVID-19 infection and their management
title_full Respiratory and cardiovascular effects of COVID-19 infection and their management
title_fullStr Respiratory and cardiovascular effects of COVID-19 infection and their management
title_full_unstemmed Respiratory and cardiovascular effects of COVID-19 infection and their management
title_short Respiratory and cardiovascular effects of COVID-19 infection and their management
title_sort respiratory and cardiovascular effects of covid-19 infection and their management
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574017/
https://www.ncbi.nlm.nih.gov/pubmed/33100642
http://dx.doi.org/10.4103/joacp.JOACP_242_20
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