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Commentary on human pluripotent stem cell-based blood–brain barrier models

In 2012, we provided the first published evidence that human pluripotent stem cells could be differentiated to cells exhibiting markers and phenotypes characteristic of the blood–brain barrier (BBB). In the ensuing years, the initial protocols have been refined, and the research community has identi...

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Autores principales: Lippmann, Ethan S., Azarin, Samira M., Palecek, Sean P., Shusta, Eric V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574179/
https://www.ncbi.nlm.nih.gov/pubmed/33076946
http://dx.doi.org/10.1186/s12987-020-00222-3
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author Lippmann, Ethan S.
Azarin, Samira M.
Palecek, Sean P.
Shusta, Eric V.
author_facet Lippmann, Ethan S.
Azarin, Samira M.
Palecek, Sean P.
Shusta, Eric V.
author_sort Lippmann, Ethan S.
collection PubMed
description In 2012, we provided the first published evidence that human pluripotent stem cells could be differentiated to cells exhibiting markers and phenotypes characteristic of the blood–brain barrier (BBB). In the ensuing years, the initial protocols have been refined, and the research community has identified both positive and negative attributes of this stem cell-based BBB model system. Here, we give our perspective on the current status of these models and their use in the BBB community, as well as highlight key attributes that would benefit from improvement moving forward.
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spelling pubmed-75741792020-10-20 Commentary on human pluripotent stem cell-based blood–brain barrier models Lippmann, Ethan S. Azarin, Samira M. Palecek, Sean P. Shusta, Eric V. Fluids Barriers CNS Commentary In 2012, we provided the first published evidence that human pluripotent stem cells could be differentiated to cells exhibiting markers and phenotypes characteristic of the blood–brain barrier (BBB). In the ensuing years, the initial protocols have been refined, and the research community has identified both positive and negative attributes of this stem cell-based BBB model system. Here, we give our perspective on the current status of these models and their use in the BBB community, as well as highlight key attributes that would benefit from improvement moving forward. BioMed Central 2020-10-19 /pmc/articles/PMC7574179/ /pubmed/33076946 http://dx.doi.org/10.1186/s12987-020-00222-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Commentary
Lippmann, Ethan S.
Azarin, Samira M.
Palecek, Sean P.
Shusta, Eric V.
Commentary on human pluripotent stem cell-based blood–brain barrier models
title Commentary on human pluripotent stem cell-based blood–brain barrier models
title_full Commentary on human pluripotent stem cell-based blood–brain barrier models
title_fullStr Commentary on human pluripotent stem cell-based blood–brain barrier models
title_full_unstemmed Commentary on human pluripotent stem cell-based blood–brain barrier models
title_short Commentary on human pluripotent stem cell-based blood–brain barrier models
title_sort commentary on human pluripotent stem cell-based blood–brain barrier models
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574179/
https://www.ncbi.nlm.nih.gov/pubmed/33076946
http://dx.doi.org/10.1186/s12987-020-00222-3
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