Leveraging locus-specific epigenetic heterogeneity to improve the performance of blood-based DNA methylation biomarkers

BACKGROUND: Variation in intercellular methylation patterns can complicate the use of methylation biomarkers for clinical diagnostic applications such as blood-based cancer testing. Here, we describe development and validation of a methylation density binary classification method called EpiClass (av...

Descripción completa

Detalles Bibliográficos
Autores principales: Miller, Brendan F., Pisanic II, Thomas R., Margolin, Gennady, Petrykowska, Hanna M., Athamanolap, Pornpat, Goncearenco, Alexander, Osei-Tutu, Akosua, Annunziata, Christina M., Wang, Tza-Huei, Elnitski, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574234/
https://www.ncbi.nlm.nih.gov/pubmed/33081832
http://dx.doi.org/10.1186/s13148-020-00939-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574234/
https://www.ncbi.nlm.nih.gov/pubmed/33081832
http://dx.doi.org/10.1186/s13148-020-00939-w

Ejemplares similares