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Leveraging locus-specific epigenetic heterogeneity to improve the performance of blood-based DNA methylation biomarkers

BACKGROUND: Variation in intercellular methylation patterns can complicate the use of methylation biomarkers for clinical diagnostic applications such as blood-based cancer testing. Here, we describe development and validation of a methylation density binary classification method called EpiClass (av...

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Detalles Bibliográficos
Autores principales:	Miller, Brendan F., Pisanic II, Thomas R., Margolin, Gennady, Petrykowska, Hanna M., Athamanolap, Pornpat, Goncearenco, Alexander, Osei-Tutu, Akosua, Annunziata, Christina M., Wang, Tza-Huei, Elnitski, Laura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574234/ https://www.ncbi.nlm.nih.gov/pubmed/33081832 http://dx.doi.org/10.1186/s13148-020-00939-w

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