Cargando…

The effects of six months Persicaria minor extract supplement among older adults with mild cognitive impairment: a double-blinded, randomized, and placebo-controlled trial

BACKGROUND: Persicaria minor extract exhibits antioxidant and anti-inflammatory properties and has potential effects on cognitive function and mood. However, the effects of P.minor on brain activation and biomarkers have not been studied among older adults. This multicentre, randomized, double-blind...

Descripción completa

Detalles Bibliográficos
Autores principales: Lau, Huijin, Shahar, Suzana, Mohamad, Mazlyfarina, Rajab, Nor Fadilah, Yahya, Hanis Mastura, Din, Normah Che, Hamid, Hamzaini Abdul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574246/
https://www.ncbi.nlm.nih.gov/pubmed/33076878
http://dx.doi.org/10.1186/s12906-020-03092-2
_version_ 1783597602534588416
author Lau, Huijin
Shahar, Suzana
Mohamad, Mazlyfarina
Rajab, Nor Fadilah
Yahya, Hanis Mastura
Din, Normah Che
Hamid, Hamzaini Abdul
author_facet Lau, Huijin
Shahar, Suzana
Mohamad, Mazlyfarina
Rajab, Nor Fadilah
Yahya, Hanis Mastura
Din, Normah Che
Hamid, Hamzaini Abdul
author_sort Lau, Huijin
collection PubMed
description BACKGROUND: Persicaria minor extract exhibits antioxidant and anti-inflammatory properties and has potential effects on cognitive function and mood. However, the effects of P.minor on brain activation and biomarkers have not been studied among older adults. This multicentre, randomized, double-blinded, placebo-controlled study aimed to investigate the effect of 6 months P.minor extract supplement (Biokesum®) on cognition, mood, biomarkers, and brain activation among older adults with Mild Cognitive Impairment (MCI). METHOD: A total of 36 Malaysian community-dwelling older adults with MCI (60–75-year-old) were randomized into Biokesum® (n = 18) and placebo group (n = 18). Each subject consumed one capsule of Biokesum® (250 mg/capsule) or placebo (maltodextrin, 280 mg/capsule) twice daily for 6 months. Cognitive function and mood were assessed at baseline, 3rd, and 6th-month using neuropsychological tests (MMSE, Digit Span, RAVLT, Digit Symbol, and Visual Reproduction) and Profile of Mood State (POMS) questionnaire. Blood lipid profile, fasting blood glucose, and biomarkers (MDA, LPO, COX-2, iNOS, and BDNF) were measured at baseline and 6th month. By the end of the intervention, there were 30 compliers (Biokesum®: N = 15; Placebo: N = 15) and 6 dropouts. For brain activation assessment, 15 subsamples (Biokesum®: N = 8; Placebo: N = 7) completed N-back and Stroop tasks during fMRI scanning at baseline and 6th month. The dorsolateral prefrontal cortex (Brodmann’s area 9 and 46) was identified as a region of interest (ROI) for brain activation analysis using SPM software. RESULTS: Two-way mixed ANOVA analysis showed significant improvements in Visual Reproduction II (p = 0.012, partial η(2) = 0.470), tension (p = 0.042, partial η(2) = 0.147), anger (p = 0.010, partial η(2) = 0.207), confusion (p = 0.041, partial η(2) = 0.148), total negative subscales (p = 0.043, partial η(2) = 0.145), BDNF (p = 0.020, partial η(2) = 0.179) and triglyceride (p = 0.029, partial η(2) = 0.237) following 6 months of Biokesum® supplementation. Preliminary finding also demonstrated significant improvement at 0-back task-induced right DLPFC activation (p = 0.028, partial η(2) = 0.652) among subsamples in Biokesum® group. No adverse events were reported at the end of the study. CONCLUSION: Six months Biokesum® supplementation potentially improved visual memory, negative mood, BDNF, and triglyceride levels among older adults with MCI. Significant findings on brain activation at the right DPLFC must be considered as preliminary. TRIAL REGISTRATION: Retrospectively registered on 30th August 2019 [ISRC TN12417552].
format Online
Article
Text
id pubmed-7574246
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-75742462020-10-20 The effects of six months Persicaria minor extract supplement among older adults with mild cognitive impairment: a double-blinded, randomized, and placebo-controlled trial Lau, Huijin Shahar, Suzana Mohamad, Mazlyfarina Rajab, Nor Fadilah Yahya, Hanis Mastura Din, Normah Che Hamid, Hamzaini Abdul BMC Complement Med Ther Research Article BACKGROUND: Persicaria minor extract exhibits antioxidant and anti-inflammatory properties and has potential effects on cognitive function and mood. However, the effects of P.minor on brain activation and biomarkers have not been studied among older adults. This multicentre, randomized, double-blinded, placebo-controlled study aimed to investigate the effect of 6 months P.minor extract supplement (Biokesum®) on cognition, mood, biomarkers, and brain activation among older adults with Mild Cognitive Impairment (MCI). METHOD: A total of 36 Malaysian community-dwelling older adults with MCI (60–75-year-old) were randomized into Biokesum® (n = 18) and placebo group (n = 18). Each subject consumed one capsule of Biokesum® (250 mg/capsule) or placebo (maltodextrin, 280 mg/capsule) twice daily for 6 months. Cognitive function and mood were assessed at baseline, 3rd, and 6th-month using neuropsychological tests (MMSE, Digit Span, RAVLT, Digit Symbol, and Visual Reproduction) and Profile of Mood State (POMS) questionnaire. Blood lipid profile, fasting blood glucose, and biomarkers (MDA, LPO, COX-2, iNOS, and BDNF) were measured at baseline and 6th month. By the end of the intervention, there were 30 compliers (Biokesum®: N = 15; Placebo: N = 15) and 6 dropouts. For brain activation assessment, 15 subsamples (Biokesum®: N = 8; Placebo: N = 7) completed N-back and Stroop tasks during fMRI scanning at baseline and 6th month. The dorsolateral prefrontal cortex (Brodmann’s area 9 and 46) was identified as a region of interest (ROI) for brain activation analysis using SPM software. RESULTS: Two-way mixed ANOVA analysis showed significant improvements in Visual Reproduction II (p = 0.012, partial η(2) = 0.470), tension (p = 0.042, partial η(2) = 0.147), anger (p = 0.010, partial η(2) = 0.207), confusion (p = 0.041, partial η(2) = 0.148), total negative subscales (p = 0.043, partial η(2) = 0.145), BDNF (p = 0.020, partial η(2) = 0.179) and triglyceride (p = 0.029, partial η(2) = 0.237) following 6 months of Biokesum® supplementation. Preliminary finding also demonstrated significant improvement at 0-back task-induced right DLPFC activation (p = 0.028, partial η(2) = 0.652) among subsamples in Biokesum® group. No adverse events were reported at the end of the study. CONCLUSION: Six months Biokesum® supplementation potentially improved visual memory, negative mood, BDNF, and triglyceride levels among older adults with MCI. Significant findings on brain activation at the right DPLFC must be considered as preliminary. TRIAL REGISTRATION: Retrospectively registered on 30th August 2019 [ISRC TN12417552]. BioMed Central 2020-10-19 /pmc/articles/PMC7574246/ /pubmed/33076878 http://dx.doi.org/10.1186/s12906-020-03092-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Lau, Huijin
Shahar, Suzana
Mohamad, Mazlyfarina
Rajab, Nor Fadilah
Yahya, Hanis Mastura
Din, Normah Che
Hamid, Hamzaini Abdul
The effects of six months Persicaria minor extract supplement among older adults with mild cognitive impairment: a double-blinded, randomized, and placebo-controlled trial
title The effects of six months Persicaria minor extract supplement among older adults with mild cognitive impairment: a double-blinded, randomized, and placebo-controlled trial
title_full The effects of six months Persicaria minor extract supplement among older adults with mild cognitive impairment: a double-blinded, randomized, and placebo-controlled trial
title_fullStr The effects of six months Persicaria minor extract supplement among older adults with mild cognitive impairment: a double-blinded, randomized, and placebo-controlled trial
title_full_unstemmed The effects of six months Persicaria minor extract supplement among older adults with mild cognitive impairment: a double-blinded, randomized, and placebo-controlled trial
title_short The effects of six months Persicaria minor extract supplement among older adults with mild cognitive impairment: a double-blinded, randomized, and placebo-controlled trial
title_sort effects of six months persicaria minor extract supplement among older adults with mild cognitive impairment: a double-blinded, randomized, and placebo-controlled trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574246/
https://www.ncbi.nlm.nih.gov/pubmed/33076878
http://dx.doi.org/10.1186/s12906-020-03092-2
work_keys_str_mv AT lauhuijin theeffectsofsixmonthspersicariaminorextractsupplementamongolderadultswithmildcognitiveimpairmentadoubleblindedrandomizedandplacebocontrolledtrial
AT shaharsuzana theeffectsofsixmonthspersicariaminorextractsupplementamongolderadultswithmildcognitiveimpairmentadoubleblindedrandomizedandplacebocontrolledtrial
AT mohamadmazlyfarina theeffectsofsixmonthspersicariaminorextractsupplementamongolderadultswithmildcognitiveimpairmentadoubleblindedrandomizedandplacebocontrolledtrial
AT rajabnorfadilah theeffectsofsixmonthspersicariaminorextractsupplementamongolderadultswithmildcognitiveimpairmentadoubleblindedrandomizedandplacebocontrolledtrial
AT yahyahanismastura theeffectsofsixmonthspersicariaminorextractsupplementamongolderadultswithmildcognitiveimpairmentadoubleblindedrandomizedandplacebocontrolledtrial
AT dinnormahche theeffectsofsixmonthspersicariaminorextractsupplementamongolderadultswithmildcognitiveimpairmentadoubleblindedrandomizedandplacebocontrolledtrial
AT hamidhamzainiabdul theeffectsofsixmonthspersicariaminorextractsupplementamongolderadultswithmildcognitiveimpairmentadoubleblindedrandomizedandplacebocontrolledtrial
AT lauhuijin effectsofsixmonthspersicariaminorextractsupplementamongolderadultswithmildcognitiveimpairmentadoubleblindedrandomizedandplacebocontrolledtrial
AT shaharsuzana effectsofsixmonthspersicariaminorextractsupplementamongolderadultswithmildcognitiveimpairmentadoubleblindedrandomizedandplacebocontrolledtrial
AT mohamadmazlyfarina effectsofsixmonthspersicariaminorextractsupplementamongolderadultswithmildcognitiveimpairmentadoubleblindedrandomizedandplacebocontrolledtrial
AT rajabnorfadilah effectsofsixmonthspersicariaminorextractsupplementamongolderadultswithmildcognitiveimpairmentadoubleblindedrandomizedandplacebocontrolledtrial
AT yahyahanismastura effectsofsixmonthspersicariaminorextractsupplementamongolderadultswithmildcognitiveimpairmentadoubleblindedrandomizedandplacebocontrolledtrial
AT dinnormahche effectsofsixmonthspersicariaminorextractsupplementamongolderadultswithmildcognitiveimpairmentadoubleblindedrandomizedandplacebocontrolledtrial
AT hamidhamzainiabdul effectsofsixmonthspersicariaminorextractsupplementamongolderadultswithmildcognitiveimpairmentadoubleblindedrandomizedandplacebocontrolledtrial