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Magnetic resonance imaging compared to ultrasonography in giant cell arteritis: a cross-sectional study

BACKGROUND: There has been a shift in recent years to using ultrasound (US) and magnetic resonance imaging (MRI) as first-line investigations for suspected cranial large vessel vasculitis (LVV) and is a new recommendation by the EULAR 2018 guidelines for imaging in LVV. This cross-sectional study co...

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Autores principales: Yip, Ashley, Jernberg, Elizabeth Torrey, Bardi, Mohammad, Geiger, Julia, Lohne, Frode, Schmidt, Wolfgang Andreas, Myklebust, Geirmund, Diamantopoulos, Andreas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574248/
https://www.ncbi.nlm.nih.gov/pubmed/33076985
http://dx.doi.org/10.1186/s13075-020-02335-4
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author Yip, Ashley
Jernberg, Elizabeth Torrey
Bardi, Mohammad
Geiger, Julia
Lohne, Frode
Schmidt, Wolfgang Andreas
Myklebust, Geirmund
Diamantopoulos, Andreas P.
author_facet Yip, Ashley
Jernberg, Elizabeth Torrey
Bardi, Mohammad
Geiger, Julia
Lohne, Frode
Schmidt, Wolfgang Andreas
Myklebust, Geirmund
Diamantopoulos, Andreas P.
author_sort Yip, Ashley
collection PubMed
description BACKGROUND: There has been a shift in recent years to using ultrasound (US) and magnetic resonance imaging (MRI) as first-line investigations for suspected cranial large vessel vasculitis (LVV) and is a new recommendation by the EULAR 2018 guidelines for imaging in LVV. This cross-sectional study compares the performance of US and MRI and contrast-enhanced magnetic resonance angiography (MRA) for detecting vasculitis in patients with giant cell arteritis (GCA). METHODS: Patients with new-onset or already diagnosed GCA were recruited. The common temporal arteries and supra-aortic large vessels were evaluated by US and MRI/MRA. Blinded experts read the images and applied a dichotomous score (vasculitis: yes/no) in each vessel. RESULTS: Thirty-seven patients with giant cell arteritis (GCA) were recruited. Two patients were excluded. Of the remaining patients, nine had new-onset disease and 26 had established disease. Mean age was 71 years, and median C-reactive protein (CRP) was 7.5 mg/L. The median time between US and MRI was 1 day. Overall, US revealed vasculitic changes more frequently than MRI (p < 0.001). US detected vascular changes in 37% of vessels compared to 21% with MRI. Among patients with chronic disease, US detected vascular changes in 23% of vessels compared to 7% with MRI in (p < 0.001). The same was true for patients with new-onset disease. US detected vasculitic changes in 22% of vessels and MRI detected disease in 6% (p = 0.0004). Compared to contrast-enhanced MRA, US was more sensitive in detecting vasculitic changes in the large arteries, including the axillary, carotid, and subclavian arteries. CONCLUSION: US more frequently detects vasculitic changes in the large arteries compared to contrast-enhanced MRA. When evaluating the cranial vessels, US performs similarly to MRI. This data supports the recommendation that US be considered as a first-line evaluation in patients suspected to have GCA.
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spelling pubmed-75742482020-10-20 Magnetic resonance imaging compared to ultrasonography in giant cell arteritis: a cross-sectional study Yip, Ashley Jernberg, Elizabeth Torrey Bardi, Mohammad Geiger, Julia Lohne, Frode Schmidt, Wolfgang Andreas Myklebust, Geirmund Diamantopoulos, Andreas P. Arthritis Res Ther Research Article BACKGROUND: There has been a shift in recent years to using ultrasound (US) and magnetic resonance imaging (MRI) as first-line investigations for suspected cranial large vessel vasculitis (LVV) and is a new recommendation by the EULAR 2018 guidelines for imaging in LVV. This cross-sectional study compares the performance of US and MRI and contrast-enhanced magnetic resonance angiography (MRA) for detecting vasculitis in patients with giant cell arteritis (GCA). METHODS: Patients with new-onset or already diagnosed GCA were recruited. The common temporal arteries and supra-aortic large vessels were evaluated by US and MRI/MRA. Blinded experts read the images and applied a dichotomous score (vasculitis: yes/no) in each vessel. RESULTS: Thirty-seven patients with giant cell arteritis (GCA) were recruited. Two patients were excluded. Of the remaining patients, nine had new-onset disease and 26 had established disease. Mean age was 71 years, and median C-reactive protein (CRP) was 7.5 mg/L. The median time between US and MRI was 1 day. Overall, US revealed vasculitic changes more frequently than MRI (p < 0.001). US detected vascular changes in 37% of vessels compared to 21% with MRI. Among patients with chronic disease, US detected vascular changes in 23% of vessels compared to 7% with MRI in (p < 0.001). The same was true for patients with new-onset disease. US detected vasculitic changes in 22% of vessels and MRI detected disease in 6% (p = 0.0004). Compared to contrast-enhanced MRA, US was more sensitive in detecting vasculitic changes in the large arteries, including the axillary, carotid, and subclavian arteries. CONCLUSION: US more frequently detects vasculitic changes in the large arteries compared to contrast-enhanced MRA. When evaluating the cranial vessels, US performs similarly to MRI. This data supports the recommendation that US be considered as a first-line evaluation in patients suspected to have GCA. BioMed Central 2020-10-19 2020 /pmc/articles/PMC7574248/ /pubmed/33076985 http://dx.doi.org/10.1186/s13075-020-02335-4 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Yip, Ashley
Jernberg, Elizabeth Torrey
Bardi, Mohammad
Geiger, Julia
Lohne, Frode
Schmidt, Wolfgang Andreas
Myklebust, Geirmund
Diamantopoulos, Andreas P.
Magnetic resonance imaging compared to ultrasonography in giant cell arteritis: a cross-sectional study
title Magnetic resonance imaging compared to ultrasonography in giant cell arteritis: a cross-sectional study
title_full Magnetic resonance imaging compared to ultrasonography in giant cell arteritis: a cross-sectional study
title_fullStr Magnetic resonance imaging compared to ultrasonography in giant cell arteritis: a cross-sectional study
title_full_unstemmed Magnetic resonance imaging compared to ultrasonography in giant cell arteritis: a cross-sectional study
title_short Magnetic resonance imaging compared to ultrasonography in giant cell arteritis: a cross-sectional study
title_sort magnetic resonance imaging compared to ultrasonography in giant cell arteritis: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574248/
https://www.ncbi.nlm.nih.gov/pubmed/33076985
http://dx.doi.org/10.1186/s13075-020-02335-4
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