High throughput single-cell detection of multiplex CRISPR-edited gene modifications

CRISPR-Cas9 gene editing has transformed our ability to rapidly interrogate the functional impact of somatic mutations in human cancers. Droplet-based technology enables the analysis of Cas9-introduced gene edits in thousands of single cells. Using this technology, we analyze Ba/F3 cells engineered...

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Detalles Bibliográficos
Autores principales: ten Hacken, Elisa, Clement, Kendell, Li, Shuqiang, Hernández-Sánchez, María, Redd, Robert, Wang, Shu, Ruff, David, Gruber, Michaela, Baranowski, Kaitlyn, Jacob, Jose, Flynn, James, Jones, Keith W., Neuberg, Donna, Livak, Kenneth J., Pinello, Luca, Wu, Catherine J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574538/
https://www.ncbi.nlm.nih.gov/pubmed/33081820
http://dx.doi.org/10.1186/s13059-020-02174-1

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