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Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease

BACKGROUND: Three amino acid differences between rodent and human APP affect medically important features, including β-secretase cleavage of APP and Aβ peptide aggregation (De Strooper et al., EMBO J 14:4932-38, 1995; Ueno et al., Biochemistry 53:7523-30, 2014; Bush, 2003, Trends Neurosci 26:207–14)...

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Detalles Bibliográficos
Autores principales:	Serneels, Lutgarde, T’Syen, Dries, Perez-Benito, Laura, Theys, Tom, Holt, Matthew G., De Strooper, Bart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574558/ https://www.ncbi.nlm.nih.gov/pubmed/33076948 http://dx.doi.org/10.1186/s13024-020-00399-z

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