Cargando…

Calcilytic NPSP795 Increases Plasma Calcium and PTH in an Autosomal Dominant Hypocalcemia Type 1 Mouse Model

Calcilytics are calcium‐sensing receptor (CaSR) antagonists that reduce the sensitivity of the CaSR to extracellular calcium. Calcilytics have the potential to treat autosomal dominant hypocalcemia type 1 (ADH1), which is caused by germline gain‐of‐function CaSR mutations and leads to symptomatic hy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hannan, Fadil M, Gorvin, Caroline M, Babinsky, Valerie N, Olesen, Mie K, Stewart, Michelle, Wells, Sara, Cox, Roger D, Nemeth, Edward F, Thakker, Rajesh V
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574706/ https://www.ncbi.nlm.nih.gov/pubmed/33103030 http://dx.doi.org/10.1002/jbm4.10402

Ejemplares similares

Gα(11) mutation in mice causes hypocalcemia rectifiable by calcilytic therapy
por: Gorvin, Caroline M., et al.
Publicado: (2017)

The Calcilytic Agent NPS 2143 Rectifies Hypocalcemia in a Mouse Model With an Activating Calcium-Sensing Receptor (CaSR) Mutation: Relevance to Autosomal Dominant Hypocalcemia Type 1 (ADH1)
por: Hannan, Fadil M., et al.
Publicado: (2015)

PTH infusion ameliorates seizures in autosomal dominant hypocalcemia type 1
por: Sastre, Ana, et al.
Publicado: (2021)

Autosomal Dominant Hypocalcemia Type 1 (ADH1) Associated With Myoclonus and Intracerebral Calcifications
por: Elston, Marianne S, et al.
Publicado: (2022)

SAT218 Refractory Hypocalcemia From Combined Autosomal Dominant Hypocalcemia Type 2 And Postsurgical Hypoparathyroidism
por: Sonmez Ince, Melda, et al.
Publicado: (2023)

Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy
por: Babinsky, Valerie N., et al.
Publicado: (2017)

Familial Hypocalciuric Hypercalcemia Type 1 and Autosomal-Dominant Hypocalcemia Type 1: Prevalence in a Large Healthcare Population
por: Dershem, Ridge, et al.
Publicado: (2020)

SAT-036 Extracellular Domain Calcium-Sensing Receptor (CaSR) Mutations Leading to Hypercalcemic and Hypocalcemic Disorders Cluster at the Homodimeric Interface
por: Olesen, Mie, et al.
Publicado: (2019)

Activating Mutations of the G-protein Subunit α (11) Interdomain Interface Cause Autosomal Dominant Hypocalcemia Type 2
por: Gorvin, Caroline M, et al.
Publicado: (2019)

Identification of a G‐Protein Subunit‐α11 Gain‐of‐Function Mutation, Val340Met, in a Family With Autosomal Dominant Hypocalcemia Type 2 (ADH2)
por: Piret, Sian E, et al.
Publicado: (2016)

Autosomal Dominant Hypocalcemia Type 1: A Systematic Review
por: Roszko, Kelly L, et al.
Publicado: (2022)

Disorders of the calcium-sensing receptor and partner proteins: insights into the molecular basis of calcium homeostasis
por: Hannan, Fadil M, et al.
Publicado: (2016)

OR30-5 Germline Ablation of G-Protein Subunit Alpha-11 in Mice Causes Hypercalcemia That Is Rectified by Treatment with Cinacalcet
por: Hannan, Fadil, et al.
Publicado: (2019)

Autosomal Dominant Hypocalcemia (Hypoparathyroidism) Types 1 and 2
por: Roszko, Kelly L., et al.
Publicado: (2016)

Amino Alcohol- (NPS-2143) and Quinazolinone-Derived Calcilytics (ATF936 and AXT914) Differentially Mitigate Excessive Signalling of Calcium-Sensing Receptor Mutants Causing Bartter Syndrome Type 5 and Autosomal Dominant Hypocalcemia
por: Letz, Saskia, et al.
Publicado: (2014)

Autosomal Dominant Hypocalcemia Type 1 and Neonatal Focal Seizures
por: Teleanu, Raluca Ioana, et al.
Publicado: (2023)

Neonatal Hypocalcemic Seizures in Offspring of a Mother With Familial Hypocalciuric Hypercalcemia Type 1 (FHH1)
por: Dharmaraj, Poonam, et al.
Publicado: (2020)

SAT-404 Neonatal Hypocalcemic Seizures in Offspring of a Mother with Familial Hypocalciuric Hypercalcemia Type 1 (FHH1)
por: Hannan, Fadil M, et al.
Publicado: (2020)

Intractable Generalized Epilepsy and Autosomal Dominant Hypocalcemia: A Case Report
por: Rossi, Gian C., et al.
Publicado: (2019)

Autosomal dominant osteopetrosis associated with renal tubular acidosis is due to a CLCN7 mutation
por: Piret, Sian E., et al.
Publicado: (2016)

PTH Gradient as a Predictor of Post Thyroidectomy Hypocalcemia
por: Garg, Surabhi, et al.
Publicado: (2021)

Synthesis of the calcilytic ligand NPS 2143
por: Johansson, Henrik, et al.
Publicado: (2013)

Autosomal Dominant Hypercalciuria in a Mouse Model Due to a Mutation of the Epithelial Calcium Channel, TRPV5
por: Loh, Nellie Y., et al.
Publicado: (2013)

Allosteric Modulation of the Calcium-sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein α-11 Mutations Causing Hypercalcemic and Hypocalcemic Disorders
por: Babinsky, Valerie N., et al.
Publicado: (2016)

MON-539 Mice Harboring a Germline Heterozygous AP2S1 Mutation, Arg15Leu, Are a Model for Familial Hypocalciuric Hypercalcemia Type 3 (FHH3)
por: Hannan, Fadil, et al.
Publicado: (2019)

PTH after Thyroidectomy as a Predictor of Post-Operative Hypocalcemia
por: Metere, Alessio, et al.
Publicado: (2021)

Hypocalcemia after thyroidectomy: iPTH levels and iPTH decline are predictive? Retrospective cohort study()
por: Cannizzaro, Matteo Angelo, et al.
Publicado: (2018)

Association Studies of Calcium-Sensing Receptor (CaSR) Polymorphisms with Serum Concentrations of Glucose and Phosphate, and Vascular Calcification in Renal Transplant Recipients
por: Babinsky, Valerie N., et al.
Publicado: (2015)

Control of PTH secretion by the TRPC1 ion channel
por: Onopiuk, Marta, et al.
Publicado: (2020)

Differential parathyroid and kidney Ca(2+)-sensing receptor activation in autosomal dominant hypocalcemia 1
por: van Megen, Wouter H., et al.
Publicado: (2022)

Autosomal dominant hypocalcemia with a novel CASR mutation: a case study and literature review
por: Wu, Yingying, et al.
Publicado: (2022)

Rare Case of Severe Hypocalcemia Due to PTH Resistance Related to Diet Pill
por: Katkar, Rujuta Baban, et al.
Publicado: (2021)

A G‐protein Subunit‐α11 Loss‐of‐Function Mutation, Thr54Met, Causes Familial Hypocalciuric Hypercalcemia Type 2 (FHH2)
por: Gorvin, Caroline M, et al.
Publicado: (2016)

Cinacalcet Rectifies Hypercalcemia in a Patient With Familial Hypocalciuric Hypercalcemia Type 2 (FHH2) Caused by a Germline Loss‐of‐Function Gα(11) Mutation
por: Gorvin, Caroline M, et al.
Publicado: (2017)

Effectiveness of an i-PTH Measurement in Predicting Post Thyroidectomy Hypocalcemia: Prospective Controlled Study
por: Kim, Jin Pyeong, et al.
Publicado: (2013)

OR21-2 Encaleret (CLTX-305) Restored Mineral Homeostasis in a Phase 2 Study in Autosomal Dominant Hypocalcemia Type 1 (ADH1)
por: Collins, Michael, et al.
Publicado: (2022)

A Phase 2B, Open-Label, Dose-Ranging Study of Encaleret (CLTX-305) in Autosomal Dominant Hypocalcemia Type 1 (ADH1)
por: Gafni, Rachel Ilana, et al.
Publicado: (2021)

Autosomal Dominant Hypocalcemia Caused by an Activating Mutation of the Calcium-Sensing Receptor Gene: The First Case Report in Korea
por: Kim, Mi Yeon, et al.
Publicado: (2010)

Hypocalcemia in COVID-19 is associated with low vitamin D levels and impaired compensatory PTH response
por: di Filippo, Luigi, et al.
Publicado: (2021)

Inhibition of Excessive Cell Proliferation by Calcilytics in Idiopathic Pulmonary Arterial Hypertension
por: Yamamura, Aya, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_vdljdqripn4rjamnnvml91lkvc