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Development and validation of the quantitative determination procedure of iodine in the iodides form in the kelp thallus by the ionometry method

INTRODUCTION: Iodine is an important compound in the kelp thallus; it should be determined to control the quality of crude herbal drugs of Laminaria sp. The ionometry method is perspective iodine (in the iodides form) determination method in the crude herbal drugs; it is characterized by the availab...

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Autores principales: Nikulin, Alexander V, Potanina, Olga G, Okuneva, Marina V, Abramovich, Rimma A, Bokov, Dmitry O, Smyslova, Olga A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574745/
https://www.ncbi.nlm.nih.gov/pubmed/33100787
http://dx.doi.org/10.4103/jpbs.JPBS_198_20
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author Nikulin, Alexander V
Potanina, Olga G
Okuneva, Marina V
Abramovich, Rimma A
Bokov, Dmitry O
Smyslova, Olga A
author_facet Nikulin, Alexander V
Potanina, Olga G
Okuneva, Marina V
Abramovich, Rimma A
Bokov, Dmitry O
Smyslova, Olga A
author_sort Nikulin, Alexander V
collection PubMed
description INTRODUCTION: Iodine is an important compound in the kelp thallus; it should be determined to control the quality of crude herbal drugs of Laminaria sp. The ionometry method is perspective iodine (in the iodides form) determination method in the crude herbal drugs; it is characterized by the availability and relative cheapness of iodide-selective electrodes and equipment in general. This method provides an effective combination of the determination step with the fast, simple, and safe step of sample preparation. AIM: The current study aims to develop and validate a simple, effective procedure for the quantitative determination of iodine in the form of iodide by ionometry in the kelp thallus (Laminaria sp.). MATERIALS AND METHODS: The determination of iodides was carried out by using the “Ecotest-120” pH meter. “Ekom-I” was used as an ion-selective electrode. Silver chloride electrode “ESR 10101” was used as a reference electrode. RESULTS AND DISCUSSION: The developed procedure has a suitable level of linearity (correlation coefficient = 0.9995%), correctness (variation coefficient = 1.58%), repeatability (variation coefficient = 6.67%), and analytical area (0.03–209.4 μg/mL analyte in the test solution). The procedure allows us to determine iodine in the form of iodides with an accuracy comparable to the accuracy of neutron activation analysis and can be recommended as an alternative to titrimetric methods existing in the world-leading pharmacopoeias.
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spelling pubmed-75747452020-10-22 Development and validation of the quantitative determination procedure of iodine in the iodides form in the kelp thallus by the ionometry method Nikulin, Alexander V Potanina, Olga G Okuneva, Marina V Abramovich, Rimma A Bokov, Dmitry O Smyslova, Olga A J Pharm Bioallied Sci Original Article INTRODUCTION: Iodine is an important compound in the kelp thallus; it should be determined to control the quality of crude herbal drugs of Laminaria sp. The ionometry method is perspective iodine (in the iodides form) determination method in the crude herbal drugs; it is characterized by the availability and relative cheapness of iodide-selective electrodes and equipment in general. This method provides an effective combination of the determination step with the fast, simple, and safe step of sample preparation. AIM: The current study aims to develop and validate a simple, effective procedure for the quantitative determination of iodine in the form of iodide by ionometry in the kelp thallus (Laminaria sp.). MATERIALS AND METHODS: The determination of iodides was carried out by using the “Ecotest-120” pH meter. “Ekom-I” was used as an ion-selective electrode. Silver chloride electrode “ESR 10101” was used as a reference electrode. RESULTS AND DISCUSSION: The developed procedure has a suitable level of linearity (correlation coefficient = 0.9995%), correctness (variation coefficient = 1.58%), repeatability (variation coefficient = 6.67%), and analytical area (0.03–209.4 μg/mL analyte in the test solution). The procedure allows us to determine iodine in the form of iodides with an accuracy comparable to the accuracy of neutron activation analysis and can be recommended as an alternative to titrimetric methods existing in the world-leading pharmacopoeias. Wolters Kluwer - Medknow 2020 2020-07-18 /pmc/articles/PMC7574745/ /pubmed/33100787 http://dx.doi.org/10.4103/jpbs.JPBS_198_20 Text en © 2020 Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Nikulin, Alexander V
Potanina, Olga G
Okuneva, Marina V
Abramovich, Rimma A
Bokov, Dmitry O
Smyslova, Olga A
Development and validation of the quantitative determination procedure of iodine in the iodides form in the kelp thallus by the ionometry method
title Development and validation of the quantitative determination procedure of iodine in the iodides form in the kelp thallus by the ionometry method
title_full Development and validation of the quantitative determination procedure of iodine in the iodides form in the kelp thallus by the ionometry method
title_fullStr Development and validation of the quantitative determination procedure of iodine in the iodides form in the kelp thallus by the ionometry method
title_full_unstemmed Development and validation of the quantitative determination procedure of iodine in the iodides form in the kelp thallus by the ionometry method
title_short Development and validation of the quantitative determination procedure of iodine in the iodides form in the kelp thallus by the ionometry method
title_sort development and validation of the quantitative determination procedure of iodine in the iodides form in the kelp thallus by the ionometry method
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574745/
https://www.ncbi.nlm.nih.gov/pubmed/33100787
http://dx.doi.org/10.4103/jpbs.JPBS_198_20
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