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Acquisition of chromosome 1q duplication in parental and genome‐edited human‐induced pluripotent stem cell‐derived neural stem cells results in their higher proliferation rate in vitro and in vivo

OBJECTIVES: Genetic engineering of human‐induced pluripotent stem cell‐derived neural stem cells (hiPSC‐NSC) may increase the risk of genomic aberrations. Therefore, we asked whether genetic modification of hiPSC‐NSCs exacerbates chromosomal abnormalities that may occur during passaging and whether...

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Detalles Bibliográficos
Autores principales:	Mehrjardi, Narges Zare, Molcanyi, Marek, Hatay, Firuze Fulya, Timmer, Marco, Shahbazi, Ebrahim, Ackermann, Justus P., Herms, Stefan, Heilmann‐Heimbach, Stefanie, Wunderlich, Thomas F., Prochnow, Nora, Haghikia, Aiden, Lampert, Angelika, Hescheler, Jürgen, Neugebauer, Edmund A. M., Baharvand, Hossein, Šarić, Tomo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574866/ https://www.ncbi.nlm.nih.gov/pubmed/32918782 http://dx.doi.org/10.1111/cpr.12892

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