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Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds angiotensin-converting enzyme 2 (ACE2) on host cells to initiate entry, and soluble ACE2 is a therapeutic candidate that neutralizes infection by acting as a decoy. By using deep mutagenesis, mutations in ACE...
Autores principales: | Chan, Kui K., Dorosky, Danielle, Sharma, Preeti, Abbasi, Shawn A., Dye, John M., Kranz, David M., Herbert, Andrew S., Procko, Erik |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574912/ https://www.ncbi.nlm.nih.gov/pubmed/32753553 http://dx.doi.org/10.1126/science.abc0870 |
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