Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy

The ongoing coronavirus disease 2019 (COVID-19) pandemic has prioritized the development of small-animal models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the respiratory tract of aged BALB/c mice. The resultin...

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Detalles Bibliográficos
Autores principales: Gu, Hongjing, Chen, Qi, Yang, Guan, He, Lei, Fan, Hang, Deng, Yong-Qiang, Wang, Yanxiao, Teng, Yue, Zhao, Zhongpeng, Cui, Yujun, Li, Yuchang, Li, Xiao-Feng, Li, Jiangfan, Zhang, Na-Na, Yang, Xiaolan, Chen, Shaolong, Guo, Yan, Zhao, Guangyu, Wang, Xiliang, Luo, De-Yan, Wang, Hui, Yang, Xiao, Li, Yan, Han, Gencheng, He, Yuxian, Zhou, Xiaojun, Geng, Shusheng, Sheng, Xiaoli, Jiang, Shibo, Sun, Shihui, Qin, Cheng-Feng, Zhou, Yusen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574913/
https://www.ncbi.nlm.nih.gov/pubmed/32732280
http://dx.doi.org/10.1126/science.abc4730

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