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Pregnancy in a healthy population: dynamics of NTproBNP and hs-cTroponin T
OBJECTIVE: To describe the intraindividual changes of heart biomarker levels during and after pregnancy and to evaluate existing cut-off levels for heart failure or myocardial ischaemia in pregnant women. METHOD: A total of 196 healthy pregnant women were recruited from maternal outpatient clinics a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574935/ https://www.ncbi.nlm.nih.gov/pubmed/33077550 http://dx.doi.org/10.1136/openhrt-2020-001293 |
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author | Furenäs, Eva Eriksson, Peter Wennerholm, Ulla-Britt Dellborg, Mikael |
author_facet | Furenäs, Eva Eriksson, Peter Wennerholm, Ulla-Britt Dellborg, Mikael |
author_sort | Furenäs, Eva |
collection | PubMed |
description | OBJECTIVE: To describe the intraindividual changes of heart biomarker levels during and after pregnancy and to evaluate existing cut-off levels for heart failure or myocardial ischaemia in pregnant women. METHOD: A total of 196 healthy pregnant women were recruited from maternal outpatient clinics and included in the study. Blood samples were obtained on four occasions: at 10–12 gestational weeks (gw), 20–25 gw, after delivery and 6 months postpartum and analysed for N-terminal pro-brain natriuretic peptide (NTproBNP) and high sensitive cardiac troponin T (hs-cTNT). Echocardiography ruled out existing cardiac disease. Estimated glomerular filtration rate (eGFR) was calculated. RESULTS: There were significant changes in NTproBNP between the measurements with the highest NTproBNP at 10–12 gw and the lowest value being at 20–25 gw, (with eGFR being the highest). Hs-cTNT was significantly higher at the peripartum measurement compared with the other measurements (p<0.05). Regardless, the 95th percentile for both biomarkers was below cut-off levels of 300 ng/L for NTproBNP and 14 ng/L for hs-cTNT. There was an association between NTproBNP above the upper limit of normal of 125 ng/L and eGFR (p=0.04) and between hs-cTNT >5.0 ng/L and time from delivery to blood sample (p=0.001) at the peripartum measurement. Both were associated with the use of oxytocin. CONCLUSION: Existing cut-off values for ruling out heart failure (NTproBNP <300 ng/L) and myocardial ischaemia (hs-cTNT <14 ng/L) are applicable during pregnancy and after delivery. Elevated levels mandate further attention on cardiac symptoms and renal function. |
format | Online Article Text |
id | pubmed-7574935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-75749352020-10-21 Pregnancy in a healthy population: dynamics of NTproBNP and hs-cTroponin T Furenäs, Eva Eriksson, Peter Wennerholm, Ulla-Britt Dellborg, Mikael Open Heart Special Populations OBJECTIVE: To describe the intraindividual changes of heart biomarker levels during and after pregnancy and to evaluate existing cut-off levels for heart failure or myocardial ischaemia in pregnant women. METHOD: A total of 196 healthy pregnant women were recruited from maternal outpatient clinics and included in the study. Blood samples were obtained on four occasions: at 10–12 gestational weeks (gw), 20–25 gw, after delivery and 6 months postpartum and analysed for N-terminal pro-brain natriuretic peptide (NTproBNP) and high sensitive cardiac troponin T (hs-cTNT). Echocardiography ruled out existing cardiac disease. Estimated glomerular filtration rate (eGFR) was calculated. RESULTS: There were significant changes in NTproBNP between the measurements with the highest NTproBNP at 10–12 gw and the lowest value being at 20–25 gw, (with eGFR being the highest). Hs-cTNT was significantly higher at the peripartum measurement compared with the other measurements (p<0.05). Regardless, the 95th percentile for both biomarkers was below cut-off levels of 300 ng/L for NTproBNP and 14 ng/L for hs-cTNT. There was an association between NTproBNP above the upper limit of normal of 125 ng/L and eGFR (p=0.04) and between hs-cTNT >5.0 ng/L and time from delivery to blood sample (p=0.001) at the peripartum measurement. Both were associated with the use of oxytocin. CONCLUSION: Existing cut-off values for ruling out heart failure (NTproBNP <300 ng/L) and myocardial ischaemia (hs-cTNT <14 ng/L) are applicable during pregnancy and after delivery. Elevated levels mandate further attention on cardiac symptoms and renal function. BMJ Publishing Group 2020-10-19 /pmc/articles/PMC7574935/ /pubmed/33077550 http://dx.doi.org/10.1136/openhrt-2020-001293 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Special Populations Furenäs, Eva Eriksson, Peter Wennerholm, Ulla-Britt Dellborg, Mikael Pregnancy in a healthy population: dynamics of NTproBNP and hs-cTroponin T |
title | Pregnancy in a healthy population: dynamics of NTproBNP and hs-cTroponin T |
title_full | Pregnancy in a healthy population: dynamics of NTproBNP and hs-cTroponin T |
title_fullStr | Pregnancy in a healthy population: dynamics of NTproBNP and hs-cTroponin T |
title_full_unstemmed | Pregnancy in a healthy population: dynamics of NTproBNP and hs-cTroponin T |
title_short | Pregnancy in a healthy population: dynamics of NTproBNP and hs-cTroponin T |
title_sort | pregnancy in a healthy population: dynamics of ntprobnp and hs-ctroponin t |
topic | Special Populations |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574935/ https://www.ncbi.nlm.nih.gov/pubmed/33077550 http://dx.doi.org/10.1136/openhrt-2020-001293 |
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