Cargando…

A nebulised antitumour necrosis factor receptor-1 domain antibody in patients at risk of postoperative lung injury: A randomised, placebo-controlled pilot study

BACKGROUND: Tumour necrosis factor receptor 1 (TNFR1) signalling mediates the cell death and inflammatory effects of TNF-α. OBJECTIVE: The current clinical trial investigated the effects of a nebulised TNFR1 antagonist (GSK2862277) on signs of lung injury in patients undergoing oesophagectomy. DESIG...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ryan, James, Bayliffe, Andrew I., McAuley, Daniel F., Yeung, Joyce, Thickett, David R., Howells, Phillip A., O’Donnell, Ciara, Vassallo, Arlette M., Wright, Tracey J., McKie, Elizabeth, Hardes, Kelly, Summers, Charlotte, Shields, Martin O., Powley, William, Wilson, Robert, Lazaar, Aili L., Fowler, Andrew, Perkins, Gavin D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2020
Materias:	Ventilation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575021/ https://www.ncbi.nlm.nih.gov/pubmed/32467417 http://dx.doi.org/10.1097/EJA.0000000000001245

Ejemplares similares

Effects of dexmedetomidine on oxygenation and lung mechanics in patients with moderate chronic obstructive pulmonary disease undergoing lung cancer surgery: A randomised double-blinded trial
por: Lee, Su Hyun, et al.
Publicado: (2016)

Neurally adjusted ventilatory assist feasibility during anaesthesia: A randomised crossover study of two anaesthetics in a large animal model
por: Jalde, Francesca Campoccia, et al.
Publicado: (2016)

Improved lung recruitment and oxygenation during mandatory ventilation with a new expiratory ventilation assistance device: A controlled interventional trial in healthy pigs
por: Schmidt, Johannes, et al.
Publicado: (2018)

Effect of positive end-expiratory pressure on gastric insufflation during induction of anaesthesia when using pressure-controlled ventilation via a face mask: A randomised controlled trial
por: Cajander, Per, et al.
Publicado: (2019)

Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications: LAS VEGAS - an observational study in 29 countries
Publicado: (2017)

Effects of positive end-expiratory pressure/recruitment manoeuvres compared with zero end-expiratory pressure on atelectasis in children: A randomised clinical trial
por: Zhu, Change, et al.
Publicado: (2021)

Intra-operative open-lung ventilatory strategy reduces postoperative complications after laparoscopic colorectal cancer resection: A randomised controlled trial
por: Li, Hong, et al.
Publicado: (2021)

Distribution of ventilation and oxygenation in surgical obese patients ventilated with high versus low positive end-expiratory pressure: A substudy of a randomised controlled trial
por: Ellenberger, Christoph, et al.
Publicado: (2022)

Individualised flow-controlled versus pressure-controlled ventilation in a porcine oleic acid-induced acute respiratory distress syndrome model
por: Abram, Julia, et al.
Publicado: (2023)

Assistive technologies for home NIV in patients with COPD: feasibility and positive experience with remote-monitoring and volume-assured auto-EPAP NIV mode
por: McDowell, Grace, et al.
Publicado: (2021)

SARS-CoV-2 environmental contamination from hospitalised patients with COVID-19 receiving aerosol-generating procedures
por: Winslow, Rebecca L, et al.
Publicado: (2022)

Elective ventilation for organ donation: law, policy and public ethics
por: Coggon, John
Publicado: (2013)

Supraglottic jet oxygenation and ventilation reduces desaturation during bronchoscopy under moderate to deep sedation with propofol and remifentanil: A randomised controlled clinical trial
por: Zha, Benjun, et al.
Publicado: (2021)

Incidence of postoperative sore throat after using a new technique of insertion of a second generation Laryngeal Mask Airway: A randomised controlled trial
por: Li, Xiaoxiao, et al.
Publicado: (2021)

Vascular endothelial growth factor receptor and coreceptor expression in human acute respiratory distress syndrome()()
por: Medford, Andrew R.L., et al.
Publicado: (2009)

Study to Explore the Association of the Renin-Angiotensin System and Right Ventricular Function in Mechanically Ventilated Patients
por: Mekontso Dessap, Armand, et al.
Publicado: (2022)

Use of bubble continuous positive airway pressure (bCPAP) in the management of critically ill children in a Malawian paediatric unit: an observational study
por: Myers, Sarah, et al.
Publicado: (2019)

Retrospective analysis of high flow nasal therapy in COVID-19-related moderate-to-severe hypoxaemic respiratory failure
por: Patel, Maulin, et al.
Publicado: (2020)

Non-invasive ventilation in obesity hypoventilation syndrome without severe obstructive sleep apnoea
por: Masa, Juan F, et al.
Publicado: (2016)

Using domiciliary non-invasive ventilator data downloads to inform clinical decision-making to optimise ventilation delivery and patient compliance
por: Mansell, Stephanie K, et al.
Publicado: (2018)

To intubate or not: ventilation is the question. A manikin-based observational study
por: Sall, Fatimata Seydou, et al.
Publicado: (2018)

Evaluation by various methods of the physiological mechanism of a high-flow nasal cannula (HFNC) in healthy volunteers
por: Okuda, Miyuki, et al.
Publicado: (2017)

Laryngeal response patterns influence the efficacy of mechanical assisted cough in amyotrophic lateral sclerosis
por: Andersen, Tiina, et al.
Publicado: (2017)

Successful awake proning is associated with improved clinical outcomes in patients with COVID-19: single-centre high-dependency unit experience
por: Hallifax, Rob J, et al.
Publicado: (2020)

Experiences and views of patients, carers and healthcare professionals on using modems in domiciliary non-invasive ventilation (NIV): a qualitative study
por: Mansell, Stephanie K, et al.
Publicado: (2020)

Home initiation of chronic non-invasive ventilation in COPD patients with chronic hypercapnic respiratory failure: a randomised controlled trial
por: Duiverman, Marieke L, et al.
Publicado: (2020)

Early NIV is associated with accelerated lung function decline in Duchenne muscular dystrophy treated with glucocorticosteroids
por: Angliss, Megan E, et al.
Publicado: (2020)

Deoxynucleoside therapy for respiratory involvement in adult patients with thymidine kinase 2-deficient myopathy
por: Hernandez-Voth, Ana, et al.
Publicado: (2020)

CPAP delivered outside critical care during the second wave of COVID-19: outcomes from a UK respiratory surge unit
por: Nightingale, Rebecca, et al.
Publicado: (2021)

Predictors of Successful Weaning from Noninvasive Ventilation in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Single-Center Retrospective Cohort Study
por: Yu, Jie, et al.
Publicado: (2021)

Improved COVID-19 outcomes in a large non-invasive respiratory support cohort despite emergence of the alpha variant
por: Turnbull, Chris D, et al.
Publicado: (2021)

Developing an intrasalivary gland botox service for patients receiving long-term non-invasive ventilation at home: a single-centre experience
por: Harbottle, Jessica, et al.
Publicado: (2022)

Factors Affecting Domiciliary Non-Invasive Ventilation Compliance
por: Shah, Amar J., et al.
Publicado: (2022)

Transitioning from hospital to home with non-invasive ventilation: who benefits? Results of a cohort study
por: Fox, Benjamin Daniel, et al.
Publicado: (2022)

Comparison of mathematically arterialised venous blood gas sampling with arterial, capillary, and venous sampling in adult patients with hypercapnic respiratory failure: a single-centre longitudinal cohort study
por: Davies, Michaael Gordon, et al.
Publicado: (2023)

A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome
por: Khan, Akram, et al.
Publicado: (2017)

Investigation of the Quantity of Exhaled Aerosols Released into the Environment during Nebulisation
por: McGrath, James A., et al.
Publicado: (2019)

Nebuliser hygiene in cystic fibrosis: evidence-based recommendations
por: Bell, Jane, et al.
Publicado: (2020)

An open‐label, dose‐escalation study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of GSK2586881 in participants with pulmonary arterial hypertension
por: Simon, Marc A., et al.
Publicado: (2022)

Validation of the Test Method—Determination of Available Carbohydrates in Cereal and Cereal Products, Dairy Products, Vegetables, Fruit, and Related Food Products and Animal Feeds: Collaborative Study, Final Action 2020.07
por: McLoughlin, Ciara, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_0unh0ndgui3hp3r0c4ika9oukc