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Differential association of air pollution exposure with neonatal and postneonatal mortality in England and Wales: A cohort study
BACKGROUND: Many but not all studies suggest an association between air pollution exposure and infant mortality. We sought to investigate whether pollution exposure is differentially associated with all-cause neonatal or postneonatal mortality, or specific causes of infant mortality. METHODS AND FIN...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575080/ https://www.ncbi.nlm.nih.gov/pubmed/33079932 http://dx.doi.org/10.1371/journal.pmed.1003400 |
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author | Kotecha, Sarah J. Watkins, W. John Lowe, John Grigg, Jonathan Kotecha, Sailesh |
author_facet | Kotecha, Sarah J. Watkins, W. John Lowe, John Grigg, Jonathan Kotecha, Sailesh |
author_sort | Kotecha, Sarah J. |
collection | PubMed |
description | BACKGROUND: Many but not all studies suggest an association between air pollution exposure and infant mortality. We sought to investigate whether pollution exposure is differentially associated with all-cause neonatal or postneonatal mortality, or specific causes of infant mortality. METHODS AND FINDINGS: We separately investigated the associations of exposure to particulate matter with aerodynamic diameter ≤ 10 μm (PM(10)), nitrogen dioxide (NO(2)), and sulphur dioxide (SO(2)) with all-cause infant, neonatal, and postneonatal mortality, and with specific causes of infant deaths in 7,984,366 live births between 2001 and 2012 in England and Wales. Overall, 51.3% of the live births were male, and there were 36,485 infant deaths (25,110 neonatal deaths and 11,375 postneonatal deaths). We adjusted for the following major confounders: deprivation, birthweight, maternal age, sex, and multiple birth. Adjusted odds ratios (95% CI; p-value) for infant deaths were significantly increased for NO(2), PM(10), and SO(2) (1.066 [1.027, 1.107; p = 0.001], 1.044 [1.007, 1.082; p = 0.017], and 1.190 [1.146, 1.235; p < 0.001], respectively) when highest and lowest pollutant quintiles were compared; however, neonatal mortality was significantly associated with SO(2) (1.207 [1.154, 1.262; p < 0.001]) but not significantly associated with NO(2) and PM(10) (1.044 [0.998, 1.092; p = 0.059] and 1.008 [0.966, 1.052; p = 0.702], respectively). Postneonatal mortality was significantly associated with all pollutants: NO(2), 1.108 (1.038, 1.182; p < 0.001); PM(10), 1.117 (1.050, 1.188; p < 0.001); and SO(2), 1.147 (1.076, 1.224; p < 0.001). Whilst all were similarly associated with endocrine causes of infant deaths (NO(2), 2.167 [1.539, 3.052; p < 0.001]; PM(10), 1.433 [1.066, 1.926; p = 0.017]; and SO(2), 1.558 [1.147, 2.116; p = 0.005]), they were differentially associated with other specific causes: NO(2) and PM(10) were associated with an increase in infant deaths from congenital malformations of the nervous (NO(2), 1.525 [1.179, 1.974; p = 0.001]; PM(10), 1.457 [1.150, 1.846; p = 0.002]) and gastrointestinal systems (NO(2), 1.214 [1.006, 1.466; p = 0.043]; PM(10), 1.312 [1.096, 1.571; p = 0.003]), and NO(2) was also associated with deaths from malformations of the respiratory system (1.306 [1.019, 1.675; p = 0.035]). In contrast, SO(2) was associated with an increase in infant deaths from perinatal causes (1.214 [1.156, 1.275; p < 0.001]) and from malformations of the circulatory system (1.172 [1.011, 1.358; p = 0.035]). A limitation of this study was that we were not able to study associations of air pollution exposure and infant mortality during the different trimesters of pregnancy. In addition, we were not able to control for all confounding factors such as maternal smoking. CONCLUSIONS: In this study, we found that NO(2), PM(10), and SO(2) were differentially associated with all-cause mortality and with specific causes of infant, neonatal, and postneonatal mortality. |
format | Online Article Text |
id | pubmed-7575080 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-75750802020-10-26 Differential association of air pollution exposure with neonatal and postneonatal mortality in England and Wales: A cohort study Kotecha, Sarah J. Watkins, W. John Lowe, John Grigg, Jonathan Kotecha, Sailesh PLoS Med Research Article BACKGROUND: Many but not all studies suggest an association between air pollution exposure and infant mortality. We sought to investigate whether pollution exposure is differentially associated with all-cause neonatal or postneonatal mortality, or specific causes of infant mortality. METHODS AND FINDINGS: We separately investigated the associations of exposure to particulate matter with aerodynamic diameter ≤ 10 μm (PM(10)), nitrogen dioxide (NO(2)), and sulphur dioxide (SO(2)) with all-cause infant, neonatal, and postneonatal mortality, and with specific causes of infant deaths in 7,984,366 live births between 2001 and 2012 in England and Wales. Overall, 51.3% of the live births were male, and there were 36,485 infant deaths (25,110 neonatal deaths and 11,375 postneonatal deaths). We adjusted for the following major confounders: deprivation, birthweight, maternal age, sex, and multiple birth. Adjusted odds ratios (95% CI; p-value) for infant deaths were significantly increased for NO(2), PM(10), and SO(2) (1.066 [1.027, 1.107; p = 0.001], 1.044 [1.007, 1.082; p = 0.017], and 1.190 [1.146, 1.235; p < 0.001], respectively) when highest and lowest pollutant quintiles were compared; however, neonatal mortality was significantly associated with SO(2) (1.207 [1.154, 1.262; p < 0.001]) but not significantly associated with NO(2) and PM(10) (1.044 [0.998, 1.092; p = 0.059] and 1.008 [0.966, 1.052; p = 0.702], respectively). Postneonatal mortality was significantly associated with all pollutants: NO(2), 1.108 (1.038, 1.182; p < 0.001); PM(10), 1.117 (1.050, 1.188; p < 0.001); and SO(2), 1.147 (1.076, 1.224; p < 0.001). Whilst all were similarly associated with endocrine causes of infant deaths (NO(2), 2.167 [1.539, 3.052; p < 0.001]; PM(10), 1.433 [1.066, 1.926; p = 0.017]; and SO(2), 1.558 [1.147, 2.116; p = 0.005]), they were differentially associated with other specific causes: NO(2) and PM(10) were associated with an increase in infant deaths from congenital malformations of the nervous (NO(2), 1.525 [1.179, 1.974; p = 0.001]; PM(10), 1.457 [1.150, 1.846; p = 0.002]) and gastrointestinal systems (NO(2), 1.214 [1.006, 1.466; p = 0.043]; PM(10), 1.312 [1.096, 1.571; p = 0.003]), and NO(2) was also associated with deaths from malformations of the respiratory system (1.306 [1.019, 1.675; p = 0.035]). In contrast, SO(2) was associated with an increase in infant deaths from perinatal causes (1.214 [1.156, 1.275; p < 0.001]) and from malformations of the circulatory system (1.172 [1.011, 1.358; p = 0.035]). A limitation of this study was that we were not able to study associations of air pollution exposure and infant mortality during the different trimesters of pregnancy. In addition, we were not able to control for all confounding factors such as maternal smoking. CONCLUSIONS: In this study, we found that NO(2), PM(10), and SO(2) were differentially associated with all-cause mortality and with specific causes of infant, neonatal, and postneonatal mortality. Public Library of Science 2020-10-20 /pmc/articles/PMC7575080/ /pubmed/33079932 http://dx.doi.org/10.1371/journal.pmed.1003400 Text en © 2020 Kotecha et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Kotecha, Sarah J. Watkins, W. John Lowe, John Grigg, Jonathan Kotecha, Sailesh Differential association of air pollution exposure with neonatal and postneonatal mortality in England and Wales: A cohort study |
title | Differential association of air pollution exposure with neonatal and postneonatal mortality in England and Wales: A cohort study |
title_full | Differential association of air pollution exposure with neonatal and postneonatal mortality in England and Wales: A cohort study |
title_fullStr | Differential association of air pollution exposure with neonatal and postneonatal mortality in England and Wales: A cohort study |
title_full_unstemmed | Differential association of air pollution exposure with neonatal and postneonatal mortality in England and Wales: A cohort study |
title_short | Differential association of air pollution exposure with neonatal and postneonatal mortality in England and Wales: A cohort study |
title_sort | differential association of air pollution exposure with neonatal and postneonatal mortality in england and wales: a cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575080/ https://www.ncbi.nlm.nih.gov/pubmed/33079932 http://dx.doi.org/10.1371/journal.pmed.1003400 |
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