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Aluminium Phosphide-Induced Expression of Covertly Present Brugada Pattern in Electrocardiogram: A Rare Case Report

Aluminum phosphide is a common suicidal agent in an agrarian country like India. Toxicity is mostly due to the liberation of phosphine gas, which non-competitively inhibits cytochrome oxidase in the mitochondria causing cell hypoxia. It can involve almost any organ in the body, but the most common i...

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Autores principales: Guru, Satyabrata, Kumar, Rajesh, Behera, Anupama, Patra, Subhabrata, Kumar, Prakash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575287/
https://www.ncbi.nlm.nih.gov/pubmed/33101800
http://dx.doi.org/10.7759/cureus.10552
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author Guru, Satyabrata
Kumar, Rajesh
Behera, Anupama
Patra, Subhabrata
Kumar, Prakash
author_facet Guru, Satyabrata
Kumar, Rajesh
Behera, Anupama
Patra, Subhabrata
Kumar, Prakash
author_sort Guru, Satyabrata
collection PubMed
description Aluminum phosphide is a common suicidal agent in an agrarian country like India. Toxicity is mostly due to the liberation of phosphine gas, which non-competitively inhibits cytochrome oxidase in the mitochondria causing cell hypoxia. It can involve almost any organ in the body, but the most common is cardiovascular system. Various cardiovascular manifestations are hypotension, myocarditis, pericarditis, congestive heart failure, various ECG changes like myocardial infarction, conduction abnormalities, various arrhythmias, and very rarely unmasking of the Brugada pattern. Here we are presenting a case in which the patient developed unmasking of the Brugada pattern in ECG, and gradually he improved symptomatically and ECG wise with conservative treatment. As unmasking of the Brugada pattern in ECG can lead to life-threatening arrhythmias, one has to be cautious and keep this in mind while dealing with a case of aluminum phosphide poisoning.
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spelling pubmed-75752872020-10-22 Aluminium Phosphide-Induced Expression of Covertly Present Brugada Pattern in Electrocardiogram: A Rare Case Report Guru, Satyabrata Kumar, Rajesh Behera, Anupama Patra, Subhabrata Kumar, Prakash Cureus Cardiology Aluminum phosphide is a common suicidal agent in an agrarian country like India. Toxicity is mostly due to the liberation of phosphine gas, which non-competitively inhibits cytochrome oxidase in the mitochondria causing cell hypoxia. It can involve almost any organ in the body, but the most common is cardiovascular system. Various cardiovascular manifestations are hypotension, myocarditis, pericarditis, congestive heart failure, various ECG changes like myocardial infarction, conduction abnormalities, various arrhythmias, and very rarely unmasking of the Brugada pattern. Here we are presenting a case in which the patient developed unmasking of the Brugada pattern in ECG, and gradually he improved symptomatically and ECG wise with conservative treatment. As unmasking of the Brugada pattern in ECG can lead to life-threatening arrhythmias, one has to be cautious and keep this in mind while dealing with a case of aluminum phosphide poisoning. Cureus 2020-09-20 /pmc/articles/PMC7575287/ /pubmed/33101800 http://dx.doi.org/10.7759/cureus.10552 Text en Copyright © 2020, Guru et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Guru, Satyabrata
Kumar, Rajesh
Behera, Anupama
Patra, Subhabrata
Kumar, Prakash
Aluminium Phosphide-Induced Expression of Covertly Present Brugada Pattern in Electrocardiogram: A Rare Case Report
title Aluminium Phosphide-Induced Expression of Covertly Present Brugada Pattern in Electrocardiogram: A Rare Case Report
title_full Aluminium Phosphide-Induced Expression of Covertly Present Brugada Pattern in Electrocardiogram: A Rare Case Report
title_fullStr Aluminium Phosphide-Induced Expression of Covertly Present Brugada Pattern in Electrocardiogram: A Rare Case Report
title_full_unstemmed Aluminium Phosphide-Induced Expression of Covertly Present Brugada Pattern in Electrocardiogram: A Rare Case Report
title_short Aluminium Phosphide-Induced Expression of Covertly Present Brugada Pattern in Electrocardiogram: A Rare Case Report
title_sort aluminium phosphide-induced expression of covertly present brugada pattern in electrocardiogram: a rare case report
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575287/
https://www.ncbi.nlm.nih.gov/pubmed/33101800
http://dx.doi.org/10.7759/cureus.10552
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