Infusion-related events during natalizumab: No need for post-infusion monitoring

This retrospective cohort study assessed the timing of infusion-related adverse events (IAEs) during natalizumab (NTZ) administration in well-documented relapsing-remitting multiple sclerosis (RRMS) patients who had received NTZ infusions in our centre between 2006 and 2018. In 225 RRMS patients (14...

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Autores principales: Loonstra, Floor C, van Rossum, Johannis A, van Kempen, Zoé LE, Rispens, Theo, Uitdehaag, Bernard MJ, Killestein, Joep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575291/
https://www.ncbi.nlm.nih.gov/pubmed/31237826
http://dx.doi.org/10.1177/1352458519860415
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author Loonstra, Floor C
van Rossum, Johannis A
van Kempen, Zoé LE
Rispens, Theo
Uitdehaag, Bernard MJ
Killestein, Joep
author_facet Loonstra, Floor C
van Rossum, Johannis A
van Kempen, Zoé LE
Rispens, Theo
Uitdehaag, Bernard MJ
Killestein, Joep
author_sort Loonstra, Floor C
collection PubMed
description This retrospective cohort study assessed the timing of infusion-related adverse events (IAEs) during natalizumab (NTZ) administration in well-documented relapsing-remitting multiple sclerosis (RRMS) patients who had received NTZ infusions in our centre between 2006 and 2018. In 225 RRMS patients (14,174 NTZ infusions), 276 IAEs (1.95%) occurred in 60 patients. All documented severe IAE occurred during infusion. Of the 19 moderate adverse events, 17 were during infusion. None of the reactions that occurred after the infusion required intervention. These results suggest that post-infusion monitoring is not necessary in patients who do not have an adverse event during infusion.
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spelling pubmed-75752912020-10-30 Infusion-related events during natalizumab: No need for post-infusion monitoring Loonstra, Floor C van Rossum, Johannis A van Kempen, Zoé LE Rispens, Theo Uitdehaag, Bernard MJ Killestein, Joep Mult Scler Short Reports This retrospective cohort study assessed the timing of infusion-related adverse events (IAEs) during natalizumab (NTZ) administration in well-documented relapsing-remitting multiple sclerosis (RRMS) patients who had received NTZ infusions in our centre between 2006 and 2018. In 225 RRMS patients (14,174 NTZ infusions), 276 IAEs (1.95%) occurred in 60 patients. All documented severe IAE occurred during infusion. Of the 19 moderate adverse events, 17 were during infusion. None of the reactions that occurred after the infusion required intervention. These results suggest that post-infusion monitoring is not necessary in patients who do not have an adverse event during infusion. SAGE Publications 2019-06-25 2020-10 /pmc/articles/PMC7575291/ /pubmed/31237826 http://dx.doi.org/10.1177/1352458519860415 Text en © The Author(s), 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Short Reports
Loonstra, Floor C
van Rossum, Johannis A
van Kempen, Zoé LE
Rispens, Theo
Uitdehaag, Bernard MJ
Killestein, Joep
Infusion-related events during natalizumab: No need for post-infusion monitoring
title Infusion-related events during natalizumab: No need for post-infusion monitoring
title_full Infusion-related events during natalizumab: No need for post-infusion monitoring
title_fullStr Infusion-related events during natalizumab: No need for post-infusion monitoring
title_full_unstemmed Infusion-related events during natalizumab: No need for post-infusion monitoring
title_short Infusion-related events during natalizumab: No need for post-infusion monitoring
title_sort infusion-related events during natalizumab: no need for post-infusion monitoring
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575291/
https://www.ncbi.nlm.nih.gov/pubmed/31237826
http://dx.doi.org/10.1177/1352458519860415
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