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CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury

Proteotoxicity from insufficient clearance of misfolded/damaged proteins underlies many diseases. Carboxyl terminus of Hsc70-interacting protein (CHIP) is an important regulator of proteostasis in many cells, having E3-ligase and chaperone functions and often directing damaged proteins towards prote...

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Detalles Bibliográficos
Autores principales:	Ranek, Mark J., Oeing, Christian, Sanchez-Hodge, Rebekah, Kokkonen-Simon, Kristen M., Dillard, Danielle, Aslam, M. Imran, Rainer, Peter P., Mishra, Sumita, Dunkerly-Eyring, Brittany, Holewinski, Ronald J., Virus, Cornelia, Zhang, Huaqun, Mannion, Matthew M., Agrawal, Vineet, Hahn, Virginia, Lee, Dong I., Sasaki, Masayuki, Van Eyk, Jennifer E., Willis, Monte S., Page, Richard C., Schisler, Jonathan C., Kass, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575552/ https://www.ncbi.nlm.nih.gov/pubmed/33082318 http://dx.doi.org/10.1038/s41467-020-18980-x

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