Multiple early introductions of SARS-CoV-2 into a global travel hub in the Middle East

International travel played a significant role in the early global spread of SARS-CoV-2. Understanding transmission patterns from different regions of the world will further inform global dynamics of the pandemic. Using data from Dubai in the United Arab Emirates (UAE), a major international travel...

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Autores principales: Tayoun, Ahmad Abou, Loney, Tom, Khansaheb, Hamda, Ramaswamy, Sathishkumar, Harilal, Divinlal, Deesi, Zulfa Omar, Varghese, Rupa Murthy, Al Suwaidi, Hanan, Alkhajeh, Abdulmajeed, AlDabal, Laila Mohamed, Uddin, Mohammed, Hamoudi, Rifat, Halwani, Rabih, Senok, Abiola, Hamid, Qutayba, Nowotny, Norbert, Alsheikh-Ali, Alawi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575574/
https://www.ncbi.nlm.nih.gov/pubmed/33082405
http://dx.doi.org/10.1038/s41598-020-74666-w
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author Tayoun, Ahmad Abou
Loney, Tom
Khansaheb, Hamda
Ramaswamy, Sathishkumar
Harilal, Divinlal
Deesi, Zulfa Omar
Varghese, Rupa Murthy
Al Suwaidi, Hanan
Alkhajeh, Abdulmajeed
AlDabal, Laila Mohamed
Uddin, Mohammed
Hamoudi, Rifat
Halwani, Rabih
Senok, Abiola
Hamid, Qutayba
Nowotny, Norbert
Alsheikh-Ali, Alawi
author_facet Tayoun, Ahmad Abou
Loney, Tom
Khansaheb, Hamda
Ramaswamy, Sathishkumar
Harilal, Divinlal
Deesi, Zulfa Omar
Varghese, Rupa Murthy
Al Suwaidi, Hanan
Alkhajeh, Abdulmajeed
AlDabal, Laila Mohamed
Uddin, Mohammed
Hamoudi, Rifat
Halwani, Rabih
Senok, Abiola
Hamid, Qutayba
Nowotny, Norbert
Alsheikh-Ali, Alawi
author_sort Tayoun, Ahmad Abou
collection PubMed
description International travel played a significant role in the early global spread of SARS-CoV-2. Understanding transmission patterns from different regions of the world will further inform global dynamics of the pandemic. Using data from Dubai in the United Arab Emirates (UAE), a major international travel hub in the Middle East, we establish SARS-CoV-2 full genome sequences from the index and early COVID-19 patients in the UAE. The genome sequences are analysed in the context of virus introductions, chain of transmissions, and possible links to earlier strains from other regions of the world. Phylogenetic analysis showed multiple spatiotemporal introductions of SARS-CoV-2 into the UAE from Asia, Europe, and the Middle East during the early phase of the pandemic. We also provide evidence for early community-based transmission and catalogue new mutations in SARS-CoV-2 strains in the UAE. Our findings contribute to the understanding of the global transmission network of SARS-CoV-2.
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spelling pubmed-75755742020-10-21 Multiple early introductions of SARS-CoV-2 into a global travel hub in the Middle East Tayoun, Ahmad Abou Loney, Tom Khansaheb, Hamda Ramaswamy, Sathishkumar Harilal, Divinlal Deesi, Zulfa Omar Varghese, Rupa Murthy Al Suwaidi, Hanan Alkhajeh, Abdulmajeed AlDabal, Laila Mohamed Uddin, Mohammed Hamoudi, Rifat Halwani, Rabih Senok, Abiola Hamid, Qutayba Nowotny, Norbert Alsheikh-Ali, Alawi Sci Rep Article International travel played a significant role in the early global spread of SARS-CoV-2. Understanding transmission patterns from different regions of the world will further inform global dynamics of the pandemic. Using data from Dubai in the United Arab Emirates (UAE), a major international travel hub in the Middle East, we establish SARS-CoV-2 full genome sequences from the index and early COVID-19 patients in the UAE. The genome sequences are analysed in the context of virus introductions, chain of transmissions, and possible links to earlier strains from other regions of the world. Phylogenetic analysis showed multiple spatiotemporal introductions of SARS-CoV-2 into the UAE from Asia, Europe, and the Middle East during the early phase of the pandemic. We also provide evidence for early community-based transmission and catalogue new mutations in SARS-CoV-2 strains in the UAE. Our findings contribute to the understanding of the global transmission network of SARS-CoV-2. Nature Publishing Group UK 2020-10-20 /pmc/articles/PMC7575574/ /pubmed/33082405 http://dx.doi.org/10.1038/s41598-020-74666-w Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Tayoun, Ahmad Abou
Loney, Tom
Khansaheb, Hamda
Ramaswamy, Sathishkumar
Harilal, Divinlal
Deesi, Zulfa Omar
Varghese, Rupa Murthy
Al Suwaidi, Hanan
Alkhajeh, Abdulmajeed
AlDabal, Laila Mohamed
Uddin, Mohammed
Hamoudi, Rifat
Halwani, Rabih
Senok, Abiola
Hamid, Qutayba
Nowotny, Norbert
Alsheikh-Ali, Alawi
Multiple early introductions of SARS-CoV-2 into a global travel hub in the Middle East
title Multiple early introductions of SARS-CoV-2 into a global travel hub in the Middle East
title_full Multiple early introductions of SARS-CoV-2 into a global travel hub in the Middle East
title_fullStr Multiple early introductions of SARS-CoV-2 into a global travel hub in the Middle East
title_full_unstemmed Multiple early introductions of SARS-CoV-2 into a global travel hub in the Middle East
title_short Multiple early introductions of SARS-CoV-2 into a global travel hub in the Middle East
title_sort multiple early introductions of sars-cov-2 into a global travel hub in the middle east
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575574/
https://www.ncbi.nlm.nih.gov/pubmed/33082405
http://dx.doi.org/10.1038/s41598-020-74666-w
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